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Target
Prostaglandin E2 receptor EP3 subtype
Ligand
BDBM50384445
Substrate
n/a
Meas. Tech.
ChEMBL_821761
Ki
7.94±n/a nM
Citation
 Jin, J; Morales-Ramos, A; Eidam, P; Mecom, J; Li, Y; Brooks, C; Hilfiker, M; Zhang, D; Wang, N; Shi, D; Tseng, PS; Wheless, K; Budzik, B; Evans, K; Jaworski, JP; Jugus, J; Leon, L; Wu, C; Pullen, M; Karamshi, B; Rao, P; Ward, E; Laping, N; Evans, C; Leach, C; Holt, D; Su, X; Morrow, D; Fries, H; Thorneloe, K; Edwards, R Novel 3-Oxazolidinedione-6-aryl-pyridinones as Potent, Selective, and Orally Active EP3 Receptor Antagonists. ACS Med Chem Lett 1:316-320 (2010) [PubMed]  Article  BDB Entry
Target
Name:
Prostaglandin E2 receptor EP3 subtype
Synonyms:
PTGER2 | Prostaglandin E2 | Prostaglandin E2 receptor EP3 subtype | Prostanoid EP3 receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
39958.37
Organism:
RAT
Description:
Prostaglandin E2 PTGER2 RAT::P34980
Residue:
365
Sequence:
MAGVWAPEHSVEAHSNQSSAADGCGSVSVAFPITMMVTGFVGNALAMLLVVRSYRRRESKRKKSFLLCIGWLALTDLVGQLLTSPVVILVYLSQRRWEQLDPSGRLCTFFGLTMTVFGLSSLLVASAMAVERALAIRAPHWYASHMKTRATPVLLGVWLSVLAFALLPVLGVGRYSVQWPGTWCFISTGPAGNETDSAREPGSVAFASAFACLGLLALVVTFACNLATIKALVSRCRAKAAASQSSAQWGRITTETAIQLMGIMCVLSVCWSPLLIMMLKMIFNQMSVEQCKTQMGKEKECNSFLIAVRLASLNQILDPWVYLLLRKILLRKFCQIRDHTNYASSSTSLPCPGSSVLMWSDQLER
  
Inhibitor
Name:
BDBM50384445
Synonyms:
CHEMBL2035508
Type:
Small organic molecule
Emp. Form.:
C20H19N3O4
Mol. Mass.:
365.3826
SMILES:
CC(C)C1(OC(=O)NC1=O)c1ccc([nH]c1=O)-c1ccc2n(C)ccc2c1
Structure:
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