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Target
Long-chain fatty acid transport protein 1
Ligand
BDBM50387705
Substrate
n/a
Meas. Tech.
ChEMBL_830659 (CHEMBL2061594)
IC50
1000±n/a nM
Citation
 Matsufuji, T; Ikeda, M; Naito, A; Hirouchi, M; Takakusa, H; Kanda, S; Izumi, M; Harada, J; Shinozuka, T Discovery and optimization of novel fatty acid transport protein 1 (FATP1) inhibitors. Bioorg Med Chem Lett 22:5067-70 (2012) [PubMed]  Article 
Target
Name:
Long-chain fatty acid transport protein 1
Synonyms:
6.2.1.- | FATP-1 | Fatp | Fatp1 | Fatty acid transport protein 1 | S27A1_MOUSE | Slc27a1 | Solute carrier family 27 member 1
Type:
PROTEIN
Mol. Mass.:
71289.41
Organism:
Mus musculus
Description:
ChEMBL_956919
Residue:
646
Sequence:
MRAPGAGTASVASLALLWFLGLPWTWSAAAAFCVYVGGGGWRFLRIVCKTARRDLFGLSVLIRVRLELRRHRRAGDTIPCIFQAVARRQPERLALVDASSGICWTFAQLDTYSNAVANLFRQLGFAPGDVVAVFLEGRPEFVGLWLGLAKAGVVAALLNVNLRREPLAFCLGTSAAKALIYGGEMAAAVAEVSEQLGKSLLKFCSGDLGPESILPDTQLLDPMLAEAPTTPLAQAPGKGMDDRLFYIYTSGTTGLPKAAIVVHSRYYRIAAFGHHSYSMRAADVLYDCLPLYHSAGNIMGVGQCVIYGLTVVLRKKFSASRFWDDCVKYNCTVVQYIGEICRYLLRQPVRDVEQRHRVRLAVGNGLRPAIWEEFTQRFGVPQIGEFYGATECNCSIANMDGKVGSCGFNSRILTHVYPIRLVKVNEDTMEPLRDSEGLCIPCQPGEPGLLVGQINQQDPLRRFDGYVSDSATNKKIAHSVFRKGDSAYLSGDVLVMDELGYMYFRDRSGDTFRWRGENVSTTEVEAVLSRLLGQTDVAVYGVAVPGVEGKAGMAAIADPHSQLDPNSMYQELQKVLASYARPIFLRLLPQVDTTGTFKIQKTRLQREGFDPRQTSDRLFFLDLKQGRYVPLDERVHARICAGDFSL
  
Inhibitor
Name:
BDBM50387705
Synonyms:
CHEMBL2058091
Type:
Small organic molecule
Emp. Form.:
C22H25N5O2S
Mol. Mass.:
423.531
SMILES:
CCC(=O)c1ccc(NC(=O)CSc2nnc(CNc3ccccc3)n2CC)cc1
Structure:
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