Reaction Details Report a problem with these data
Target
Nuclear receptor subfamily 1 group D member 1
Ligand
BDBM50388637
Substrate
n/a
Meas. Tech.
ChEMBL_829091 (CHEMBL2060741)
EC50
5500±n/a nM
Citation
 Shin, Y; Noel, R; Banerjee, S; Kojetin, D; Song, X; He, Y; Lin, L; Cameron, MD; Burris, TP; Kamenecka, TM Small molecule tertiary amines as agonists of the nuclear hormone receptor Rev-erba. Bioorg Med Chem Lett 22:4413-7 (2012) [PubMed]  Article 
Target
Name:
Nuclear receptor subfamily 1 group D member 1
Synonyms:
EAR-1 | EAR1 | HREV | NR1D1 | NR1D1_HUMAN | Rev-erbA-alpha | THRAL | V-erbA-related protein 1
Type:
PROTEIN
Mol. Mass.:
66822.11
Organism:
Homo sapiens (Human)
Description:
ChEMBL_958222
Residue:
614
Sequence:
MTTLDSNNNTGGVITYIGSSGSSPSRTSPESLYSDNSNGSFQSLTQGCPTYFPPSPTGSLTQDPARSFGSIPPSLSDDGSPSSSSSSSSSSSSFYNGSPPGSLQVAMEDSSRVSPSKSTSNITKLNGMVLLCKVCGDVASGFHYGVHACEGCKGFFRRSIQQNIQYKRCLKNENCSIVRINRNRCQQCRFKKCLSVGMSRDAVRFGRIPKREKQRMLAEMQSAMNLANNQLSSQCPLETSPTQHPTPGPMGPSPPPAPVPSPLVGFSQFPQQLTPPRSPSPEPTVEDVISQVARAHREIFTYAHDKLGSSPGNFNANHASGSPPATTPHRWENQGCPPAPNDNNTLAAQRHNEALNGLRQAPSSYPPTWPPGPAHHSCHQSNSNGHRLCPTHVYAAPEGKAPANSPRQGNSKNVLLACPMNMYPHGRSGRTVQEIWEDFSMSFTPAVREVVEFAKHIPGFRDLSQHDQVTLLKAGTFEVLMVRFASLFNVKDQTVMFLSRTTYSLQELGAMGMGDLLSAMFDFSEKLNSLALTEEELGLFTAVVLVSADRSGMENSASVEQLQETLLRALRALVLKNRPLETSRFTKLLLKLPDLRTLNNMHSEKLLSFRVDAQ
  
Inhibitor
Name:
BDBM50388637
Synonyms:
CHEMBL2059555
Type:
Small organic molecule
Emp. Form.:
C20H16ClF3N2O2S
Mol. Mass.:
440.866
SMILES:
[O-][N+](=O)c1ccc(CN(Cc2ccc(Cl)cc2)Cc2ccc(cc2)C(F)(F)F)s1
Structure:
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