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Target
N-acylethanolamine-hydrolyzing acid amidase
Ligand
BDBM50389008
Substrate
n/a
Meas. Tech.
ChEMBL_832910 (CHEMBL2066781)
IC50
700±n/a nM
Citation
 Duranti, A; Tontini, A; Antonietti, F; Vacondio, F; Fioni, A; Silva, C; Lodola, A; Rivara, S; Solorzano, C; Piomelli, D; Tarzia, G; Mor, M N-(2-oxo-3-oxetanyl)carbamic acid esters as N-acylethanolamine acid amidase inhibitors: synthesis and structure-activity and structure-property relationships. J Med Chem 55:4824-36 (2012) [PubMed]  Article 
Target
Name:
N-acylethanolamine-hydrolyzing acid amidase
Synonyms:
ASAH-like protein | Asahl | N-acylethanolamine acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase | N-acylethanolamine-hydrolyzing acid amidase (NAAA) | N-acylethanolamine-hydrolyzing acid amidase subunit alpha | N-acylethanolamine-hydrolyzing acid amidase subunit beta | N-acylsphingosine amidohydrolase-like | NAAA_RAT | Naaa
Type:
Enzyme
Mol. Mass.:
40306.53
Organism:
Rattus norvegicus (Rat)
Description:
Q5KTC7
Residue:
362
Sequence:
MGTPAIRAACHGAHLALALLLLLSLSDPWLWATAPGTPPLFNVSLDAAPELRWLPMLQHYDPDFVRAAVAQVIGDRVPQWILEMIGEIVQKVESFLPQPFTSEIRGICDYLNLSLAEGVLVNLAYEASAFCTSIVAQDSQGRIYHGRNLDYPFGNALRKLTADVQFVKNGQIVFTATTFVGYVGLWTGQSPHKFTISGDERDKGWWWENMIAALSLGHSPISWLIRKTLTESEDFEAAVYTLAKTPLIADVYYIVGGTSPQEGVVITRDRGGPADIWPLDPLNGAWFRVETNYDHWEPVPKRDDRRTPAIKALNATGQAHLSLETLFQVLSVFPVYNNYTIYTTVMSAAEPDKYMTMIRNPS
  
Inhibitor
Name:
BDBM50389008
Synonyms:
CHEMBL2064167 | US9321743, URB785
Type:
Small organic molecule
Emp. Form.:
C11H11NO4
Mol. Mass.:
221.2093
SMILES:
O=C(N[C@@H]1COC1=O)OCc1ccccc1 |r|
Structure:
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