Reaction Details Report a problem with these data
Target
Calcium/calmodulin-dependent protein kinase type IV
Ligand
BDBM50389241
Substrate
n/a
Meas. Tech.
ChEMBL_831564 (CHEMBL2064927)
IC50
>10000±n/a nM
Citation
 Ji, Z; Dai, Y; Abad-Zapatero, C; Albert, DH; Bouska, JJ; Glaser, KB; Marcotte, PA; Soni, NB; Magoc, TJ; Stewart, KD; Wei, RQ; Davidsen, SK; Michaelides, MR Exploration of diverse hinge-binding scaffolds for selective Aurora kinase inhibitors. Bioorg Med Chem Lett 22:4528-31 (2012) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type IV
Synonyms:
CAM kinase-GR | CAMK | CAMK-GR | CAMK4 | CAMKIV | CaM kinase IV | CaMK IV | Calcium/calmodulin-dependent protein kinase type IV | KCC4_HUMAN
Type:
PROTEIN
Mol. Mass.:
51919.87
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1459854
Residue:
473
Sequence:
MLKVTVPSCSASSCSSVTASAAPGTASLVPDYWIDGSNRDALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTVDKKIVRTEIGVLLRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHENGIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEILRGCAYGPEVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDPKKRLTTFQALQHPWVTGKAANFVHMDTAQKKLQEFNARRKLKAAVKAVVASSRLGSASSSHGSIQESHKASRDPSPIQDGNEDMKAIPEGEKIQGDGAQAAVKGAQAELMKVQALEKVKGADINAEEAPKMVPKAVEDGIKVADLELEEGLAEEKLKTVEEAAAPREGQGSSAVGFEVPQQDVILPEY
  
Inhibitor
Name:
BDBM50389241
Synonyms:
CHEMBL1990583
Type:
Small organic molecule
Emp. Form.:
C20H16FN7O2
Mol. Mass.:
405.3851
SMILES:
Nc1ncnn2ccc(C(=O)Nc3ccc(NC(=O)Nc4cccc(F)c4)cc3)c12
Structure:
Search PDB for entries with ligand similarity: