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Target
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Ligand
BDBM17471
Substrate
n/a
Meas. Tech.
ChEMBL_832078 (CHEMBL2065520)
IC50
38000±n/a nM
Citation
 Galli, U; Mesenzani, O; Coppo, C; Sorba, G; Canonico, PL; Tron, GC; Genazzani, AA Identification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2. Eur J Med Chem 55:58-66 (2012) [PubMed]  Article 
Target
Name:
NAD-dependent protein deacetylase sirtuin-3, mitochondrial
Synonyms:
NAD-dependent deacetylase sirtuin 3 | NAD-dependent protein deacetylase sirtuin-3 (SIRT3) | SIR2L3 | SIR3_HUMAN | SIRT3
Type:
Protein
Mol. Mass.:
43582.69
Organism:
Homo sapiens (Human)
Description:
Q9NTG7
Residue:
399
Sequence:
MAFWGWRAAAALRLWGRVVERVEAGGGVGPFQACGCRLVLGGRDDVSAGLRGSHGARGEPLDPARPLQRPPRPEVPRAFRRQPRAAAPSFFFSSIKGGRRSISFSVGASSVVGSGGSSDKGKLSLQDVAELIRARACQRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDLPYPEAIFELPFFFHNPKPFFTLAKELYPGNYKPNVTHYFLRLLHDKGLLLRLYTQNIDGLERVSGIPASKLVEAHGTFASATCTVCQRPFPGEDIRADVMADRVPRCPVCTGVVKPDIVFFGEPLPQRFLLHVVDFPMADLLLILGTSLEVEPFASLTEAVRSSVPRLLINRDLVGPLAWHPRSRDVAQLGDVVHGVESLVELLGWTEEMRDLVQRETGKLDGPDK
  
Inhibitor
Name:
BDBM17471
Synonyms:
1,2,3-triazole analogue, 27 | 3-(1H-1,2,3-triazol-5-yl)pyridine
Type:
Small organic molecule
Emp. Form.:
C7H6N4
Mol. Mass.:
146.1493
SMILES:
c1[nH]nnc1-c1cccnc1
Structure:
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