Reaction Details Report a problem with these data
Target
Corticotropin-releasing factor receptor 1
Ligand
BDBM50389528
Substrate
n/a
Meas. Tech.
ChEMBL_832415 (CHEMBL2067139)
IC50
115±n/a nM
Citation
 Takeda, K; Terauchi, T; Hashizume, M; Shin, K; Ino, M; Shibata, H; Yonaga, M Design, synthesis, and structure-activity relationships of a series of 2-Ar-8-methyl-5-alkylaminoquinolines as novel CRF1 receptor antagonists. Bioorg Med Chem Lett 22:5372-8 (2012) [PubMed]  Article 
Target
Name:
Corticotropin-releasing factor receptor 1
Synonyms:
CRF-R | CRF-R2 Alpha | CRF1 | CRFR | CRFR1 | CRFR1_HUMAN | CRH-R 1 | CRHR | CRHR1 | Corticotropin releasing factor receptor 1 | Corticotropin-releasing factor receptor 1 (CRF-1) | Corticotropin-releasing factor receptor 1 (CRF1) | Corticotropin-releasing hormone receptor 1
Type:
Enzyme
Mol. Mass.:
50744.31
Organism:
Homo sapiens (Human)
Description:
P34998
Residue:
444
Sequence:
MGGHPQLRLVKALLLLGLNPVSASLQDQHCESLSLASNISGLQCNASVDLIGTCWPRSPAGQLVVRPCPAFFYGVRYNTTNNGYRECLANGSWAARVNYSECQEILNEEKKSKVHYHVAVIINYLGHCISLVALLVAFVLFLRLRPGCTHWGDQADGALEVGAPWSGAPFQVRRSIRCLRNIIHWNLISAFILRNATWFVVQLTMSPEVHQSNVGWCRLVTAAYNYFHVTNFFWMFGEGCYLHTAIVLTYSTDRLRKWMFICIGWGVPFPIIVAWAIGKLYYDNEKCWFGKRPGVYTDYIYQGPMILVLLINFIFLFNIVRILMTKLRASTTSETIQYRKAVKATLVLLPLLGITYMLFFVNPGEDEVSRVVFIYFNSFLESFQGFFVSVFYCFLNSEVRSAIRKRWHRWQDKHSIRARVARAMSIPTSPTRVSFHSIKQSTAV
  
Inhibitor
Name:
BDBM50389528
Synonyms:
CHEMBL2063370
Type:
Small organic molecule
Emp. Form.:
C28H38N2O3
Mol. Mass.:
450.6129
SMILES:
CCCN(CCC)c1ccc(CC)c2nc(c(C)cc12)-c1c(OC)cc(COC)cc1OC |(56.46,9.32,;56.46,7.78,;55.13,6.99,;55.14,5.45,;56.48,4.68,;57.81,5.46,;59.14,4.69,;53.81,4.67,;52.47,5.44,;51.14,4.67,;51.14,3.12,;49.81,2.35,;48.47,3.12,;52.47,2.36,;52.47,.82,;53.81,.04,;55.15,.82,;56.48,.05,;55.14,2.36,;53.81,3.12,;53.81,-1.49,;52.47,-2.26,;51.14,-1.49,;49.81,-2.26,;52.47,-3.8,;53.81,-4.57,;53.81,-6.11,;52.48,-6.88,;51.14,-6.12,;55.14,-3.79,;55.14,-2.26,;56.47,-1.49,;57.81,-2.25,)|
Structure:
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