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Target
11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50390700
Substrate
n/a
Meas. Tech.
ChEMBL_835666 (CHEMBL2071777)
IC50
362±n/a nM
Citation
 Valeur, E; Christmann-Franck, S; Lepifre, F; Carniato, D; Cravo, D; Charon, C; Bozec, S; Musil, D; Hillertz, P; Doare, L; Schmidlin, F; Lecomte, M; Schultz, M; Roche, D Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11ß-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett 22:5909-14 (2012) [PubMed]  Article 
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase 1 | 11beta-HSD1A | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | DHI1_MOUSE | Hsd11 | Hsd11b1
Type:
Enzyme
Mol. Mass.:
32369.70
Organism:
Mus musculus (mouse)
Description:
P50172
Residue:
292
Sequence:
MAVMKNYLLPILVLFLAYYYYSTNEEFRPEMLQGKKVIVTGASKGIGREMAYHLSKMGAHVVLTARSEEGLQKVVSRCLELGAASAHYIAGTMEDMTFAEQFIVKAGKLMGGLDMLILNHITQTSLSLFHDDIHSVRRVMEVNFLSYVVMSTAALPMLKQSNGSIAVISSLAGKMTQPMIAPYSASKFALDGFFSTIRTELYITKVNVSITLCVLGLIDTETAMKEISGIINAQASPKEECALEIIKGTALRKSEVYYDKSPLTPILLGNPGRKIMEFFSLRYYNKDMFVSN
  
Inhibitor
Name:
BDBM50390700
Synonyms:
CHEMBL2070227
Type:
Small organic molecule
Emp. Form.:
C21H21N3O
Mol. Mass.:
331.4109
SMILES:
O=C(N1CCC(C1)c1c[nH]c2ncccc12)C1(CC1)c1ccccc1
Structure:
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