Reaction Details
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11-beta-hydroxysteroid dehydrogenase 1
Ligand
BDBM50390711
Substrate
n/a
Meas. Tech.
ChEMBL_835662 (CHEMBL2071773)
IC50
439±n/a nM
Citation
Valeur, E; Christmann-Franck, S; Lepifre, F; Carniato, D; Cravo, D; Charon, C; Bozec, S; Musil, D; Hillertz, P; Doare, L; Schmidlin, F; Lecomte, M; Schultz, M; Roche, D Structure-based design of 7-azaindole-pyrrolidine amides as inhibitors of 11ß-hydroxysteroid dehydrogenase type I. Bioorg Med Chem Lett 22:5909-14 (2012) [PubMed] Article More Info.:
Target
Name:
11-beta-hydroxysteroid dehydrogenase 1
Synonyms:
11-DH | 11-beta-HSD1 | 11-beta-Hydroxysteroid Dehydrogenase 1 (11-beta-HSD1) | 11-beta-hydroxysteroid dehydrogenase | 11-beta-hydroxysteroid dehydrogenase 1 (11HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD-1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11-beta-HSD1) | Corticosteroid 11-beta-dehydrogenase isozyme 1 (11beta-HSD1) | DHI1_HUMAN | HSD11 | HSD11B1 | HSD11L | SDR26C1
Type:
Enzyme
Mol. Mass.:
32409.16
Organism:
Homo sapiens (Human)
Description:
P28845
Residue:
292
Sequence:
MAFMKKYLLPILGLFMAYYYYSANEEFRPEMLQGKKVIVTGASKGIGREMAYHLAKMGAHVVVTARSKETLQKVVSHCLELGAASAHYIAGTMEDMTFAEQFVAQAGKLMGGLDMLILNHITNTSLNLFHDDIHHVRKSMEVNFLSYVVLTVAALPMLKQSNGSIVVVSSLAGKVAYPMVAAYSASKFALDGFFSSIRKEYSVSRVNVSITLCVLGLIDTETAMKAVSGIVHMQAAPKEECALEIIKGGALRQEEVYYDSSLWTTLLIRNPCRKILEFLYSTSYNMDRFINK
Inhibitor
Name:
BDBM50390711
Synonyms:
CHEMBL2070320
Type:
Small organic molecule
Emp. Form.:
C21H19F2N3O
Mol. Mass.:
367.3919
SMILES:
Fc1ccc(cc1)C1(CC1)C(=O)N1CCC(C1)c1c[nH]c2ncc(F)cc12
Structure:
