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Target
Solute carrier family 22 member 2
Ligand
BDBM50036754
Substrate
n/a
Meas. Tech.
ChEMBL_837507 (CHEMBL2075995)
Ki
1800000±n/a nM
Citation
 Motohashi, H; Uwai, Y; Hiramoto, K; Okuda, M; Inui, K Different transport properties between famotidine and cimetidine by human renal organic ion transporters (SLC22A). Eur J Pharmacol 503:25-30 (2004) [PubMed]  Article 
Target
Name:
Solute carrier family 22 member 2
Synonyms:
OCT2 | Organic cation transporter 2 | S22A2_HUMAN | SLC22A2 | hOCT2
Type:
PROTEIN
Mol. Mass.:
62591.01
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1484077
Residue:
555
Sequence:
MPTTVDDVLEHGGEFHFFQKQMFFLLALLSATFAPIYVGIVFLGFTPDHRCRSPGVAELSLRCGWSPAEELNYTVPGPGPAGEASPRQCRRYEVDWNQSTFDCVDPLASLDTNRSRLPLGPCRDGWVYETPGSSIVTEFNLVCANSWMLDLFQSSVNVGFFIGSMSIGYIADRFGRKLCLLTTVLINAAAGVLMAISPTYTWMLIFRLIQGLVSKAGWLIGYILITEFVGRRYRRTVGIFYQVAYTVGLLVLAGVAYALPHWRWLQFTVSLPNFFFLLYYWCIPESPRWLISQNKNAEAMRIIKHIAKKNGKSLPASLQRLRLEEETGKKLNPSFLDLVRTPQIRKHTMILMYNWFTSSVLYQGLIMHMGLAGDNIYLDFFYSALVEFPAAFMIILTIDRIGRRYPWAASNMVAGAACLASVFIPGDLQWLKIIISCLGRMGITMAYEIVCLVNAELYPTFIRNLGVHICSSMCDIGGIITPFLVYRLTNIWLELPLMVFGVLGLVAGGLVLLLPETKGKALPETIEEAENMQRPRKNKEKMIYLQVQKLDIPLN
  
Inhibitor
Name:
BDBM50036754
Synonyms:
(1Z)-N'-(aminosulfonyl)-3-[({2-[(diaminomethylene)amino]-1,3-thiazol-4-yl}methyl)thio]propanimidamide | (1Z)-N'-(aminosulfonyl)-3-[({2-[(diaminomethylene)amino]-1,3-thiazol-4-yl}methyl)thio]propanimidamide (Famotidine) | 3-(2-Guanidino-thiazol-4-ylmethylsulfanyl)-N-sulfonylamino-propionamidine | CHEMBL902 | FAMOTIDINE | Fluxid | MK-208 | N'-(aminosulfonyl)-3-(((2-((diaminomethylene)amino)-4-thiazolyl)methyl)thio)propanimidamide | N-sulfomoyl-3-(2-Guanidino-2H-1lambda*4*-thiazol-4-ylmethylsulfanyl)-propionamidine | Pepcid | Pepcid ac | Pepcid ac (geltab) | Pepcid rpd
Type:
Small organic molecule
Emp. Form.:
C8H15N7O2S3
Mol. Mass.:
337.445
SMILES:
[#7]\[#6](-[#7])=[#7]/c1nc(-[#6]-[#16]-[#6]-[#6]-[#6](=[#7])-[#7]S([#7])(=O)=O)cs1
Structure:
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