Reaction Details Report a problem with these data
Target
Exopolyphosphatase PRUNE1
Ligand
BDBM23620
Substrate
n/a
Meas. Tech.
ChEMBL_840281 (CHEMBL2091189)
IC50
780±n/a nM
Citation
 Virgilio, A; Spano, D; Esposito, V; Di Dato, V; Citarella, G; Marino, N; Maffia, V; De Martino, D; De Antonellis, P; Galeone, A; Zollo, M Novel pyrimidopyrimidine derivatives for inhibition of cellular proliferation and motility induced by h-prune in breast cancer. Eur J Med Chem 57:41-50 (2012) [PubMed]  Article 
Target
Name:
Exopolyphosphatase PRUNE1
Synonyms:
DRES-17 | DRES17 | Drosophila-related expressed sequence 17 | HTcD37 | hPrune | PRUN1_HUMAN | PRUNE1 | PRUNE | Protein prune homolog
Type:
PROTEIN
Mol. Mass.:
50187.97
Organism:
Human
Description:
ChEMBL_840282
Residue:
453
Sequence:
MEDYLQGCRAALQESRPLHVVLGNEACDLDSTVSALALAFYLAKTTEAEEVFVPVLNIKRSELPLRGDIVFFLQKVHIPESILIFRDEIDLHALYQAGQLTLILVDHHILSKSDTALEEAVAEVLDHRPIEPKHCPPCHVSVELVGSCATLVTERILQGAPEILDRQTAALLHGTIILDCVNMDLKIGKATPKDSKYVEKLEALFPDLPKRNDIFDSLQKAKFDVSGLTTEQMLRKDQKTIYRQGVKVAISAIYMDLEAFLQRSNLLADLHAFCQAHSYDVLVAMTIFFNTHNEPVRQLAIFCPHVALQTTICEVLERSHSPPLKLTPASSTHPNLHAYLQGNTQVSRKKLLPLLQEALSAYFDSMKIPSGQPETADVSREQVDKELDRASNSLISGLSQDEEDPPLPPTPMNSLVDECPLDQGLPKLSAEAVFEKCSQISLSQSTTASLSKK
  
Inhibitor
Name:
BDBM23620
Synonyms:
Dipyridamine | SMR000058382 | MLS000028420 | CHEMBL932 | 2-({6-[bis(2-hydroxyethyl)amino]-4,8-bis(piperidin-1-yl)pyrimido[5,4-d][1,3]diazin-2-yl}(2-hydroxyethyl)amino)ethan-1-ol | cid_3108 | Dipyudamine | Persantine | Dipyridamole
Type:
Small organic molecule
Emp. Form.:
C24H40N8O4
Mol. Mass.:
504.32
SMILES:
C1CCN(CC1)c2c3c(c(nc(n3)N(CCO)CCO)N4CCCCC4)nc(n2)N(CCO)CCO
Structure:
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