Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50391389
Substrate
n/a
Meas. Tech.
ChEMBL_848925 (CHEMBL2149719)
Ki
5.9±n/a nM
Citation
 Chen, J; Levant, B; Wang, S High-affinity and selective dopamine D3 receptor full agonists. Bioorg Med Chem Lett 22:5612-7 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50391389
Synonyms:
CHEMBL2148215
Type:
Small organic molecule
Emp. Form.:
C28H37N5OS
Mol. Mass.:
491.691
SMILES:
CCCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1cccc2cnccc12)[C@H]1CCc2nc(N)sc2C1 |r,wU:9.12,wD:25.27,6.5,(-2.33,-4.62,;-2.33,-3.08,;-3.67,-2.31,;-3.67,-.77,;-2.34,.01,;-1,-.76,;.33,.01,;1.67,-.76,;3,0,;3,1.55,;1.66,2.32,;.32,1.55,;4.34,2.31,;5.67,1.54,;5.67,,;7.01,2.31,;7,3.85,;8.33,4.62,;9.67,3.85,;9.67,2.3,;11,1.54,;11,0,;9.66,-.77,;8.33,-0,;8.33,1.54,;-4.94,.1,;-4.5,1.57,;-5.54,2.7,;-7.03,2.34,;-8.3,3.23,;-9.53,2.3,;-11,2.76,;-9.03,.85,;-7.48,.88,;-6.44,-.24,)|
Structure:
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