Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50391395
Substrate
n/a
Meas. Tech.
ChEMBL_848925 (CHEMBL2149719)
Ki
3.5±n/a nM
Citation
 Chen, J; Levant, B; Wang, S High-affinity and selective dopamine D3 receptor full agonists. Bioorg Med Chem Lett 22:5612-7 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50391395
Synonyms:
CHEMBL2146501
Type:
Small organic molecule
Emp. Form.:
C30H40N6O2S
Mol. Mass.:
548.743
SMILES:
CCCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc(cc1)-c1noc(n1)C1CC1)[C@H]1CCc2nc(N)sc2C1 |r,wU:9.12,wD:29.32,6.5,(-5.02,-5.58,;-5.01,-4.04,;-6.33,-3.26,;-6.32,-1.72,;-4.98,-.96,;-3.65,-1.74,;-2.31,-.99,;-.99,-1.78,;.35,-1.03,;.37,.52,;-.96,1.3,;-2.31,.55,;1.71,1.27,;3.04,.48,;3.02,-1.06,;4.38,1.24,;5.7,.45,;7.03,1.2,;7.06,2.74,;5.73,3.53,;4.39,2.77,;8.33,3.61,;8.36,5.14,;9.84,5.58,;10.72,4.31,;9.78,3.09,;12.26,4.28,;13.57,3.48,;13.61,5.02,;-7.58,-.84,;-7.12,.62,;-8.16,1.76,;-9.65,1.42,;-10.9,2.33,;-12.14,1.41,;-13.61,1.88,;-11.66,-.05,;-10.11,-.04,;-9.08,-1.16,)|
Structure:
Search PDB for entries with ligand similarity: