Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50391396
Substrate
n/a
Meas. Tech.
ChEMBL_848925 (CHEMBL2149719)
Ki
0.68±n/a nM
Citation
 Chen, J; Levant, B; Wang, S High-affinity and selective dopamine D3 receptor full agonists. Bioorg Med Chem Lett 22:5612-7 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50391396
Synonyms:
CHEMBL2146511
Type:
Small organic molecule
Emp. Form.:
C24H35ClN4O2S2
Mol. Mass.:
511.143
SMILES:
CCCN(CC[C@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccccc1Cl)[C@H]1CCc2nc(N)sc2C1 |r,wU:9.12,wD:23.24,6.5,(-1.75,-4.55,;-1.74,-3.01,;-3.07,-2.23,;-3.05,-.69,;-1.71,.07,;-.38,-.71,;.96,.05,;2.28,-.75,;3.62,.01,;3.64,1.55,;2.31,2.33,;.96,1.58,;4.98,2.3,;6.3,1.52,;7.06,.19,;5.53,.19,;7.65,2.27,;7.67,3.8,;9.01,4.55,;10.34,3.76,;10.31,2.21,;8.96,1.47,;8.93,-.07,;-4.32,.19,;-3.85,1.66,;-4.89,2.79,;-6.38,2.46,;-7.64,3.36,;-8.87,2.44,;-10.34,2.91,;-8.39,.98,;-6.84,.99,;-5.81,-.13,)|
Structure:
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