Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50391401
Substrate
n/a
Meas. Tech.
ChEMBL_848925 (CHEMBL2149719)
Ki
0.73±n/a nM
Citation
 Chen, J; Levant, B; Wang, S High-affinity and selective dopamine D3 receptor full agonists. Bioorg Med Chem Lett 22:5612-7 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50391401
Synonyms:
CHEMBL2146503
Type:
Small organic molecule
Emp. Form.:
C28H38N6O2S
Mol. Mass.:
522.705
SMILES:
CCCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1cccc(c1)-c1noc(C)n1)[C@H]1CCc2nc(N)sc2C1 |r,wU:9.12,wD:27.29,6.5,(-3.55,-4.55,;-3.54,-3.01,;-4.86,-2.23,;-4.85,-.69,;-3.51,.07,;-2.18,-.72,;-.84,.04,;.48,-.75,;1.82,0,;1.84,1.54,;.51,2.33,;-.83,1.58,;3.18,2.3,;4.51,1.51,;4.49,-.03,;5.85,2.26,;5.86,3.8,;7.2,4.55,;8.53,3.77,;8.51,2.23,;7.17,1.47,;9.76,1.34,;11.22,1.82,;12.14,.58,;11.24,-.67,;11.72,-2.14,;9.77,-.2,;-6.11,.19,;-5.65,1.65,;-6.68,2.79,;-8.18,2.45,;-9.43,3.36,;-10.67,2.44,;-12.14,2.91,;-10.19,.98,;-8.64,.99,;-7.61,-.14,)|
Structure:
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