Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50391402
Substrate
n/a
Meas. Tech.
ChEMBL_848925 (CHEMBL2149719)
Ki
1.5±n/a nM
Citation
 Chen, J; Levant, B; Wang, S High-affinity and selective dopamine D3 receptor full agonists. Bioorg Med Chem Lett 22:5612-7 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50391402
Synonyms:
CHEMBL2146505
Type:
Small organic molecule
Emp. Form.:
C28H38N4O2S2
Mol. Mass.:
526.757
SMILES:
CCCN(CC[C@H]1CC[C@@H](CC1)NS(=O)(=O)c1cccc2ccccc12)[C@H]1CCc2nc(N)sc2C1 |r,wU:9.12,wD:26.28,6.5,(-2.4,-4.56,;-2.38,-3.01,;-3.71,-2.23,;-3.7,-.69,;-2.36,.07,;-1.03,-.71,;.31,.05,;1.64,-.75,;2.98,.01,;3,1.55,;1.67,2.33,;.32,1.58,;4.34,2.3,;5.66,1.52,;6.42,.19,;4.89,.19,;7.01,2.27,;7.03,3.8,;8.37,4.56,;9.7,3.76,;9.68,2.22,;10.99,1.42,;10.96,-.11,;9.61,-.86,;8.29,-.06,;8.32,1.47,;-4.96,.19,;-4.5,1.66,;-5.53,2.79,;-7.03,2.46,;-8.28,3.36,;-9.52,2.44,;-10.99,2.91,;-9.04,.98,;-7.49,.99,;-6.46,-.13,)|
Structure:
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