Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50391408
Substrate
n/a
Meas. Tech.
ChEMBL_848925 (CHEMBL2149719)
Ki
1.3±n/a nM
Citation
 Chen, J; Levant, B; Wang, S High-affinity and selective dopamine D3 receptor full agonists. Bioorg Med Chem Lett 22:5612-7 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50391408
Synonyms:
CHEMBL2148222
Type:
Small organic molecule
Emp. Form.:
C28H38N6O2S
Mol. Mass.:
522.705
SMILES:
CCCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc(cc1)-c1noc(C)n1)[C@H]1CCc2nc(N)sc2C1 |r,wU:9.12,wD:27.29,6.5,(-4.35,-5.59,;-4.33,-4.05,;-5.66,-3.26,;-5.65,-1.72,;-4.31,-.96,;-2.98,-1.75,;-1.64,-.99,;-.31,-1.78,;1.03,-1.03,;1.05,.52,;-.28,1.3,;-1.63,.55,;2.39,1.27,;3.72,.48,;3.7,-1.06,;5.06,1.24,;6.38,.45,;7.72,1.2,;7.74,2.74,;6.41,3.53,;5.07,2.77,;9.01,3.61,;9.05,5.14,;10.53,5.59,;11.4,4.32,;12.95,4.28,;10.47,3.09,;-6.91,-.84,;-6.45,.62,;-7.48,1.76,;-8.98,1.43,;-10.23,2.33,;-11.47,1.41,;-12.95,1.88,;-10.99,-.05,;-9.44,-.04,;-8.41,-1.17,)|
Structure:
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