Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50391409
Substrate
n/a
Meas. Tech.
ChEMBL_848925 (CHEMBL2149719)
Ki
4.5±n/a nM
Citation
 Chen, J; Levant, B; Wang, S High-affinity and selective dopamine D3 receptor full agonists. Bioorg Med Chem Lett 22:5612-7 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50391409
Synonyms:
CHEMBL2146513
Type:
Small organic molecule
Emp. Form.:
C27H42N4O2S2
Mol. Mass.:
518.778
SMILES:
CCCN(CC[C@H]1CC[C@@H](CC1)NS(=O)(=O)c1ccc(cc1)C(C)C)[C@H]1CCc2nc(N)sc2C1 |r,wU:9.12,wD:25.26,6.5,(-3.09,-5.3,;-3.07,-3.76,;-4.4,-2.98,;-4.39,-1.44,;-3.05,-.68,;-1.72,-1.46,;-.38,-.7,;.95,-1.49,;2.28,-.74,;2.3,.8,;.98,1.59,;-.37,.83,;3.65,1.55,;4.96,.77,;5.73,-.56,;4.19,-.55,;6.31,1.52,;6.33,3.05,;7.67,3.8,;9,3.01,;8.97,1.47,;7.63,.72,;10.35,3.76,;11.67,2.97,;10.38,5.3,;-5.65,-.55,;-5.19,.91,;-6.22,2.04,;-7.71,1.71,;-8.97,2.61,;-10.2,1.7,;-11.67,2.16,;-9.72,.23,;-8.18,.25,;-7.15,-.88,)|
Structure:
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