Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50391411
Substrate
n/a
Meas. Tech.
ChEMBL_848925 (CHEMBL2149719)
Ki
1.1±n/a nM
Citation
 Chen, J; Levant, B; Wang, S High-affinity and selective dopamine D3 receptor full agonists. Bioorg Med Chem Lett 22:5612-7 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50391411
Synonyms:
CHEMBL2148219
Type:
Small organic molecule
Emp. Form.:
C28H38N6OS
Mol. Mass.:
506.706
SMILES:
CCCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1cccc(c1)-n1ccnc1)[C@H]1CCc2nc(N)sc2C1 |r,wU:9.12,wD:26.28,6.5,(-3.58,-4.55,;-3.57,-3.01,;-4.89,-2.23,;-4.88,-.69,;-3.54,.07,;-2.21,-.72,;-.87,.04,;.45,-.75,;1.79,0,;1.81,1.54,;.48,2.33,;-.87,1.58,;3.15,2.3,;4.48,1.51,;4.46,-.03,;5.82,2.26,;5.83,3.8,;7.17,4.55,;8.5,3.77,;8.47,2.23,;7.14,1.47,;9.79,1.45,;11.26,1.93,;12.17,.69,;11.26,-.56,;9.8,-.09,;-6.14,.19,;-5.68,1.65,;-6.72,2.79,;-8.21,2.45,;-9.46,3.36,;-10.7,2.44,;-12.17,2.91,;-10.22,.98,;-8.67,.99,;-7.64,-.14,)|
Structure:
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