Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50391417
Substrate
n/a
Meas. Tech.
ChEMBL_848925 (CHEMBL2149719)
Ki
8.1±n/a nM
Citation
 Chen, J; Levant, B; Wang, S High-affinity and selective dopamine D3 receptor full agonists. Bioorg Med Chem Lett 22:5612-7 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50391417
Synonyms:
CHEMBL2148212
Type:
Small organic molecule
Emp. Form.:
C28H40N4O2S
Mol. Mass.:
496.708
SMILES:
CCCN(CC[C@H]1CC[C@@H](CC1)NC(=O)\C=C\c1ccccc1OC)[C@H]1CCc2nc(N)sc2C1 |r,wU:9.12,wD:25.26,6.5,(-2.99,-4.61,;-2.99,-3.07,;-4.33,-2.3,;-4.33,-.76,;-3,.01,;-1.67,-.76,;-.33,.02,;1,-.76,;2.33,.01,;2.33,1.55,;1,2.32,;-.34,1.55,;3.67,2.32,;5,1.54,;5,0,;6.33,2.31,;7.66,1.54,;9,2.31,;8.99,3.84,;10.32,4.61,;11.66,3.84,;11.66,2.3,;10.32,1.53,;10.32,-.01,;8.98,-.77,;-5.6,.11,;-5.16,1.57,;-6.21,2.7,;-7.69,2.35,;-8.96,3.23,;-10.18,2.31,;-11.66,2.76,;-9.69,.85,;-8.14,.88,;-7.1,-.24,)|
Structure:
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