Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50391418
Substrate
n/a
Meas. Tech.
ChEMBL_848925 (CHEMBL2149719)
Ki
2.4±n/a nM
Citation
 Chen, J; Levant, B; Wang, S High-affinity and selective dopamine D3 receptor full agonists. Bioorg Med Chem Lett 22:5612-7 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50391418
Synonyms:
CHEMBL2148221
Type:
Small organic molecule
Emp. Form.:
C27H37N7OS
Mol. Mass.:
507.694
SMILES:
CCCN(CC[C@H]1CC[C@@H](CC1)NC(=O)c1ccc(cc1)-n1cncn1)[C@H]1CCc2nc(N)sc2C1 |r,wU:9.12,wD:26.28,6.5,(-3.58,-5.59,;-3.57,-4.05,;-4.89,-3.26,;-4.88,-1.72,;-3.54,-.96,;-2.21,-1.75,;-.87,-.99,;.46,-1.78,;1.79,-1.03,;1.82,.52,;.49,1.3,;-.86,.55,;3.16,1.27,;4.49,.48,;4.47,-1.06,;5.83,1.24,;7.15,.45,;8.49,1.2,;8.51,2.74,;7.18,3.53,;5.84,2.77,;9.78,3.61,;9.82,5.14,;11.3,5.59,;12.17,4.32,;11.23,3.09,;-6.14,-.84,;-5.68,.62,;-6.72,1.76,;-8.21,1.43,;-9.47,2.33,;-10.7,1.41,;-12.17,1.88,;-10.23,-.05,;-8.67,-.04,;-7.64,-1.17,)|
Structure:
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