Reaction Details Report a problem with these data
Target
D(3) dopamine receptor
Ligand
BDBM50391425
Substrate
n/a
Meas. Tech.
ChEMBL_848930 (CHEMBL2149724)
EC50
1.5±n/a nM
Citation
 Chen, J; Levant, B; Wang, S High-affinity and selective dopamine D3 receptor full agonists. Bioorg Med Chem Lett 22:5612-7 (2012) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3 | DRD3_HUMAN | Dopamine D3 receptor | Dopamine D3 receptor (D3) | Dopamine D3 receptor (D3R) | Dopamine receptor | Dopamine receptor (D3) | Dopamine receptor D3
Type:
n/a
Mol. Mass.:
44243.43
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
400
Sequence:
MASLSQLSSHLNYTCGAENSTGASQARPHAYYALSYCALILAIVFGNGLVCMAVLKERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPTVCSISNPDFVIYSSVVSFYLPFGVTVLVYARIYVVLKQRRRKRILTRQNSQCNSVRPGFPQQTLSPDPAHLELKRYYSICQDTALGGPGFQERGGELKREEKTRNSLSPTIAPKLSLEVRKLSNGRLSTSLKLGPLQPRGVPLREKKATQMVAIVLGAFIVCWLPFFLTHVLNTHCQTCHVSPELYSATTWLGYVNSALNPVIYTTFNIEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50391425
Synonyms:
CHEMBL2146499
Type:
Small organic molecule
Emp. Form.:
C23H34ClN5O2S2
Mol. Mass.:
512.131
SMILES:
CCCN(CC[C@H]1CC[C@@H](CC1)NS(=O)(=O)c1cccnc1Cl)[C@H]1CCc2nc(N)sc2C1 |r,wU:9.12,wD:23.24,6.5,(-1.75,-4.56,;-1.74,-3.01,;-3.07,-2.23,;-3.05,-.69,;-1.71,.07,;-.38,-.71,;.96,.05,;2.28,-.75,;3.62,.01,;3.64,1.55,;2.31,2.33,;.96,1.58,;4.99,2.3,;6.31,1.52,;7.07,.19,;5.53,.19,;7.66,2.27,;7.67,3.8,;9.01,4.56,;10.35,3.76,;10.32,2.22,;8.97,1.47,;8.94,-.07,;-4.32,.19,;-3.86,1.66,;-4.89,2.79,;-6.39,2.46,;-7.64,3.36,;-8.88,2.45,;-10.35,2.91,;-8.4,.98,;-6.85,.99,;-5.82,-.13,)|
Structure:
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