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Target
Dual specificity protein phosphatase 4
Ligand
BDBM50387974
Substrate
n/a
Meas. Tech.
ChEMBL_848110 (CHEMBL2148511)
IC50
>100000±n/a nM
Citation
 Park, H; Chien, PN; Ryu, SE Discovery of potent inhibitors of receptor protein tyrosine phosphatase sigma through the structure-based virtual screening. Bioorg Med Chem Lett 22:6333-7 (2012) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 4
Synonyms:
DUS4_HUMAN | DUSP4 | Dual specificity protein phosphatase hVH2 | MAP kinase phosphatase 2 | MKP-2 | MKP2 | Mitogen-activated protein kinase phosphatase 2 | VH2
Type:
PROTEIN
Mol. Mass.:
42957.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_848110
Residue:
394
Sequence:
MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGYILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC
  
Inhibitor
Name:
BDBM50387974
Synonyms:
CHEMBL2057830
Type:
Small organic molecule
Emp. Form.:
C18H12N4O4S
Mol. Mass.:
380.377
SMILES:
Oc1ccc(cc1)C1=NN2C(S1)=NC(=O)\C(=C\c1ccc(O)c(O)c1)C2=N |c:13,t:8|
Structure:
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