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Target
Dual specificity protein phosphatase 4
Ligand
BDBM50391714
Substrate
n/a
Meas. Tech.
ChEMBL_848110 (CHEMBL2148511)
IC50
21000±n/a nM
Citation
 Park, H; Chien, PN; Ryu, SE Discovery of potent inhibitors of receptor protein tyrosine phosphatase sigma through the structure-based virtual screening. Bioorg Med Chem Lett 22:6333-7 (2012) [PubMed]  Article 
Target
Name:
Dual specificity protein phosphatase 4
Synonyms:
DUS4_HUMAN | DUSP4 | Dual specificity protein phosphatase hVH2 | MAP kinase phosphatase 2 | MKP-2 | MKP2 | Mitogen-activated protein kinase phosphatase 2 | VH2
Type:
PROTEIN
Mol. Mass.:
42957.74
Organism:
Homo sapiens (Human)
Description:
ChEMBL_848110
Residue:
394
Sequence:
MVTMEELREMDCSVLKRLMNRDENGGGAGGSGSHGTLGLPSGGKCLLLDCRPFLAHSAGYILGSVNVRCNTIVRRRAKGSVSLEQILPAEEEVRARLRSGLYSAVIVYDERSPRAESLREDSTVSLVVQALRRNAERTDICLLKGGYERFSSEYPEFCSKTKALAAIPPPVPPSATEPLDLGCSSCGTPLHDQGGPVEILPFLYLGSAYHAARRDMLDALGITALLNVSSDCPNHFEGHYQYKCIPVEDNHKADISSWFMEAIEYIDAVKDCRGRVLVHCQAGISRSATICLAYLMMKKRVRLEEAFEFVKQRRSIISPNFSFMGQLLQFESQVLATSCAAEAASPSGPLRERGKTPATPTSQFVFSFPVSVGVHSAPSSLPYLHSPITTSPSC
  
Inhibitor
Name:
BDBM50391714
Synonyms:
CHEMBL2146957
Type:
Small organic molecule
Emp. Form.:
C26H18ClN3O2S2
Mol. Mass.:
504.023
SMILES:
SC1=NC(=O)C(S1)=Cc1cn(nc1-c1cccc(OCc2ccccc2Cl)c1)-c1ccccc1 |w:7.8,t:1|
Structure:
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