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Target
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Ligand
BDBM50163745
Substrate
n/a
Meas. Tech.
ChEMBL_848194 (CHEMBL2148930)
IC50
680±n/a nM
Citation
 Mayadevi, M; Sherin, DR; Keerthi, VS; Rajasekharan, KN; Omkumar, RV Curcumin is an inhibitor of calcium/calmodulin dependent protein kinase II. Bioorg Med Chem 20:6040-7 (2012) [PubMed]  Article 
Target
Name:
Calcium/calmodulin-dependent protein kinase type II subunit alpha
Synonyms:
CAMK2A | CAMKA | CaM kinase II | CaM kinase II alpha | Calcium/calmodulin-dependent protein kinase type II subunit alpha (CAMK2a) | KCC2A_HUMAN | KIAA0968
Type:
Enzyme Catalytic Domain
Mol. Mass.:
54093.63
Organism:
Homo sapiens (Human)
Description:
gi_25952118
Residue:
478
Sequence:
MATITCTRFTEEYQLFEELGKGAFSVVRRCVKVLAGQEYAAKIINTKKLSARDHQKLEREARICRLLKHPNIVRLHDSISEEGHHYLIFDLVTGGELFEDIVAREYYSEADASHCIQQILEAVLHCHQMGVVHRDLKPENLLLASKLKGAAVKLADFGLAIEVEGEQQAWFGFAGTPGYLSPEVLRKDPYGKPVDLWACGVILYILLVGYPPFWDEDQHRLYQQIKAGAYDFPSPEWDTVTPEAKDLINKMLTINPSKRITAAEALKHPWISHRSTVASCMHRQETVDCLKKFNARRKLKGAILTTMLATRNFSGGKSGGNKKSDGVKESSESTNTTIEDEDTKVRKQEIIKVTEQLIEAISNGDFESYTKMCDPGMTAFEPEALGNLVEGLDFHRFYFENLWSRNSKPVHTTILNPHIHLMGDESACIAYIRITQYLDAGGIPRTAQSEETRVWHRRDGKWQIVHFHRSGAPSVLPH
  
Inhibitor
Name:
BDBM50163745
Synonyms:
4,40-(1E,10E)-2,20-(Isoxazole-3,5-diyl)bis(ethene-2,1-diyl)bis(2-methoxyphenol) | 4-((E)-2-{3-[(E)-2-(4-hydroxy-3-methoxyphenyl)vinyl]isoxazol-5-yl}vinyl)-2-methoxyphenol | 4-(-2-(5-(4-hydroxy-3-methoxystyryl)isoxazol-3-yl)vinyl)-2-methoxyphenol | 4-(2-(5-(4-hydroxy-3-methoxystyryl)isoxazol-3-yl)vinyl)-2-methoxyphenol | CHEMBL181529
Type:
Small organic molecule
Emp. Form.:
C21H19NO5
Mol. Mass.:
365.3793
SMILES:
COc1cc(\C=C\c2cc(\C=C\c3ccc(O)c(OC)c3)on2)ccc1O
Structure:
Search PDB for entries with ligand similarity: