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Target
Hydroxysteroid 11-beta dehydrogenase 1
Ligand
BDBM50392216
Substrate
n/a
Meas. Tech.
ChEMBL_850498 (CHEMBL2157619)
IC50
3770±n/a nM
Citation
 Scott, JS; Bowker, SS; Deschoolmeester, J; Gerhardt, S; Hargreaves, D; Kilgour, E; Lloyd, A; Mayers, RM; McCoull, W; Newcombe, NJ; Ogg, D; Packer, MJ; Rees, A; Revill, J; Schofield, P; Selmi, N; Swales, JG; Whittamore, PR Discovery of a potent, selective, and orally bioavailable acidic 11ß-hydroxysteroid dehydrogenase type 1 (11ß-HSD1) inhibitor: discovery of 2-[(3S)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanylpyridin-2-yl]-3-piperidyl]acetic acid (AZD4017). J Med Chem 55:5951-64 (2012) [PubMed]  Article 
Target
Name:
Hydroxysteroid 11-beta dehydrogenase 1
Synonyms:
11-beta-hydroxysteroid dehydrogenase type 1
Type:
PROTEIN
Mol. Mass.:
32020.70
Organism:
Canis familiaris
Description:
ChEMBL_850498
Residue:
293
Sequence:
MAFKKKYLPPLLGFFLAYYYYSANEEFRPEMLQGKKVIVTGASKGIGEQMAYHLAKMGAHVVVTARSKETLKKVVSHCLELGAASAHYIPGTMEDMTFAEQFVAKAGKLMGGLDMLILNHITNTSMNLFSGDIHLVRRSMEVNFLSYVVLSAAALPMLKQSNGSIVVVSSKAGKMSSPLVAPYSASKFALDGFFSSVRMEHSVTKVNVSITLCILGLINTDTAMKAVSGILSTVGASSKEECALEIIKGGALRQEEVYYDNSVWTAFLLGNPGRKILEFLSLRSYKLDKFINN
  
Inhibitor
Name:
BDBM50392216
Synonyms:
CHEMBL2153191 | US8673938, 7
Type:
Small organic molecule
Emp. Form.:
C22H33N3O3S
Mol. Mass.:
419.581
SMILES:
CCCSc1nc(ccc1C(=O)NC1CCCCC1)N1CCC[C@@H](CC(O)=O)C1 |r|
Structure:
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