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Target
Cholesteryl ester transfer protein
Ligand
BDBM50392526
Substrate
n/a
Meas. Tech.
ChEMBL_852277 (CHEMBL2155543)
IC50
1740±n/a nM
Citation
 Miller, MM; Liu, Y; Jiang, J; Johnson, JA; Kamau, M; Nirschl, DS; Wang, Y; Harikrishnan, L; Taylor, DS; Chen, AY; Yin, X; Seethala, R; Peterson, TL; Zvyaga, T; Zhang, J; Huang, CS; Wexler, RR; Poss, MA; Lawrence, RM; Adam, LP; Salvati, ME Identification of a potent and metabolically stable series of fluorinated diphenylpyridylethanamine-based cholesteryl ester transfer protein inhibitors. Bioorg Med Chem Lett 22:6503-8 (2012) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50392526
Synonyms:
CHEMBL2152179
Type:
Small organic molecule
Emp. Form.:
C25H23ClF5N3O2
Mol. Mass.:
527.914
SMILES:
CCCNC(=O)N[C@@](Cc1ccccc1)(c1cc(F)cc(OC(F)(F)C(F)F)c1)c1ccc(Cl)cn1 |r|
Structure:
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