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Target
Mitogen-activated protein kinase 9
Ligand
BDBM50392850
Substrate
n/a
Meas. Tech.
ChEMBL_853353 (CHEMBL2155143)
IC50
2200±n/a nM
Citation
 Kaoud, TS; Yan, C; Mitra, S; Tseng, CC; Jose, J; Taliaferro, JM; Tuohetahuntila, M; Devkota, A; Sammons, R; Park, J; Park, H; Shi, Y; Hong, J; Ren, P; Dalby, KN From in Silico Discovery to intra-Cellular Activity: Targeting JNK-Protein Interactions with Small Molecules. ACS Med Chem Lett 3:721-725 (2012) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 9
Synonyms:
JNK-55 | JNK2 | JNK2/JNK3 | MAPK9 | MK09_HUMAN | Mitogen-Activated Protein Kinase 9 (JNK2) | Mitogen-activated protein kinase 8/9 | PRKM9 | SAPK1A | Stress-activated protein kinase JNK2 | c-Jun N-terminal kinase 2 | c-Jun N-terminal kinase 2 (JNK2)
Type:
Enzyme
Mol. Mass.:
48131.49
Organism:
Homo sapiens (Human)
Description:
JNK-2 was purchased from Upstate Cell Signaling Solutions (formerly Upstate Biotechnology).
Residue:
424
Sequence:
MSDSKCDSQFYSVQVADSTFTVLKRYQQLKPIGSGAQGIVCAAFDTVLGINVAVKKLSRPFQNQTHAKRAYRELVLLKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIHMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTACTNFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGELVKGCVIFQGTDHIDQWNKVIEQLGTPSAEFMKKLQPTVRNYVENRPKYPGIKFEELFPDWIFPSESERDKIKTSQARDLLSKMLVIDPDKRISVDEALRHPYITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
  
Inhibitor
Name:
BDBM50392850
Synonyms:
CHEMBL2151191
Type:
Small organic molecule
Emp. Form.:
C20H20O5
Mol. Mass.:
340.3698
SMILES:
C[C@H]1[C@@H](C)[C@H](O[C@@H]1c1ccc2OCOc2c1)c1ccc2OCOc2c1 |r|
Structure:
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