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Target
2-oxoglutarate receptor 1
Ligand
BDBM50393143
Substrate
n/a
Meas. Tech.
ChEMBL_852825 (CHEMBL2155424)
IC50
>30000±n/a nM
Citation
 Bhuniya, D; Umrani, D; Dave, B; Salunke, D; Kukreja, G; Gundu, J; Naykodi, M; Shaikh, NS; Shitole, P; Kurhade, S; De, S; Majumdar, S; Reddy, SB; Tambe, S; Shejul, Y; Chugh, A; Palle, VP; Mookhtiar, KA; Cully, D; Vacca, J; Chakravarty, PK; Nargund, RP; Wright, SD; Graziano, MP; Singh, SB; Roy, S; Cai, TQ Discovery of a potent and selective small molecule hGPR91 antagonist. Bioorg Med Chem Lett 21:3596-602 (2011) [PubMed]  Article 
Target
Name:
2-oxoglutarate receptor 1
Synonyms:
Alpha-ketoglutarate receptor 1 | G-protein coupled receptor 80 | G-protein coupled receptor 99 | GPR80 | GPR99 | OXGR1 | OXGR1_HUMAN | P2RY15 | P2Y purinoceptor 15 | P2Y-like GPCR | P2Y-like nucleotide receptor | P2Y15
Type:
PROTEIN
Mol. Mass.:
38261.32
Organism:
Homo sapiens (Human)
Description:
ChEMBL_852825
Residue:
337
Sequence:
MNEPLDYLANASDFPDYAAAFGNCTDENIPLKMHYLPVIYGIIFLVGFPGNAVVISTYIFKMRPWKSSTIIMLNLACTDLLYLTSLPFLIHYYASGENWIFGDFMCKFIRFSFHFNLYSSILFLTCFSIFRYCVIIHPMSCFSIHKTRCAVVACAVVWIISLVAVIPMTFLITSTNRTNRSACLDLTSSDELNTIKWYNLILTATTFCLPLVIVTLCYTTIIHTLTHGLQTDSCLKQKARRLTILLLLAFYVCFLPFHILRVIRIESRLLSISCSIENQIHEAYIVSRPLAALNTFGNLLLYVVVSDNFQQAVCSTVRCKVSGNLEQAKKISYSNNP
  
Inhibitor
Name:
BDBM50393143
Synonyms:
CHEMBL2153581
Type:
Small organic molecule
Emp. Form.:
C23H18F4N4O2
Mol. Mass.:
458.4082
SMILES:
Fc1ccc(cc1C(F)(F)F)-c1cc(CNC(=O)CCCc2ccc3cccnc3n2)on1
Structure:
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