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Target
Serine protease SplB
Ligand
BDBM50395601
Substrate
n/a
Meas. Tech.
ChEMBL_859707 (CHEMBL2169142)
Ki
>200000±n/a nM
Citation
 Ewa, B; Maciej, W; Marcin, S; Grzegorz, D; Michal, Z; Jan, P; Józef, O The development of first Staphylococcus aureus SplB protease inhibitors: phosphonic analogues of glutamine. Bioorg Med Chem Lett 22:5574-8 (2012) [PubMed]  Article 
Target
Name:
Serine protease SplB
Synonyms:
SPLB_STAAU | splB
Type:
PROTEIN
Mol. Mass.:
26147.73
Organism:
Staphylococcus aureus
Description:
ChEMBL_859707
Residue:
240
Sequence:
MNKNVVIKSLATLTILTSVTGIGTTLVEEVQQTAKAENNVTKIQDTNIFPYTGVVAFKSATGFVVGKNTILTNKHVSKNYKVGDRITAHPNSDKGNGGIYSIKKIINYPGKEDVSVIQVEERAIERGPKGFNFNDNVTPFKYAAGAKAGERIKVIGYPHPYKNKYVLYESTGPVMSVEGSSIVYSAHTESGNSGSPVLNSNNELVGIHFASDVKNDDNRNAYGVYFTPEIKKFIAENIDK
  
Inhibitor
Name:
BDBM50395601
Synonyms:
CHEMBL2165303
Type:
Small organic molecule
Emp. Form.:
C32H41N2O6P
Mol. Mass.:
580.6515
SMILES:
CC(C)(C)c1ccc(OP(=O)(Oc2ccc(cc2)C(C)(C)C)C(CCC(N)=O)NC(=O)OCc2ccccc2)cc1
Structure:
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