Reaction Details Report a problem with these data
Target
Histone-lysine N-methyltransferase SUV39H1
Ligand
BDBM50134315
Substrate
n/a
Meas. Tech.
ChEMBL_861232 (CHEMBL2173370)
IC50
260±n/a nM
Citation
 Decarlo, D; Hadden, MK Oncoepigenomics: making histone lysine methylation count. Eur J Med Chem 56:179-194 (2012) [PubMed]  Article 
Target
Name:
Histone-lysine N-methyltransferase SUV39H1
Synonyms:
H3-K9-HMTase 1 | Histone H3-K9 methyltransferase 1 | KMT1A | Lysine N-methyltransferase 1A | Position-effect variegation 3-9 homolog | SUV39H | SUV39H1 | SUV91_HUMAN | Su(var)3-9 homolog 1 | Suppressor of variegation 3-9 homolog 1
Type:
PROTEIN
Mol. Mass.:
47917.07
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1473655
Residue:
412
Sequence:
MAENLKGCSVCCKSSWNQLQDLCRLAKLSCPALGISKRNLYDFEVEYLCDYKKIREQEYYLVKWRGYPDSESTWEPRQNLKCVRILKQFHKDLERELLRRHHRSKTPRHLDPSLANYLVQKAKQRRALRRWEQELNAKRSHLGRITVENEVDLDGPPRAFVYINEYRVGEGITLNQVAVGCECQDCLWAPTGGCCPGASLHKFAYNDQGQVRLRAGLPIYECNSRCRCGYDCPNRVVQKGIRYDLCIFRTDDGRGWGVRTLEKIRKNSFVMEYVGEIITSEEAERRGQIYDRQGATYLFDLDYVEDVYTVDAAYYGNISHFVNHSCDPNLQVYNVFIDNLDERLPRIAFFATRTIRAGEELTFDYNMQVDPVDMESTRMDSNFGLAGLPGSPKKRVRIECKCGTESCRKYLF
  
Inhibitor
Name:
BDBM50134315
Synonyms:
7-hydroxy-11-hydroxymethyl-12-methyl-14,15-dithia-9,12-diazatetracyclo[9.2.2.01,9.03,8]pentadeca-3,5-diene-10,13-dione | CHEMBL331627 | GLIOTOXIN
Type:
Small organic molecule
Emp. Form.:
C13H14N2O4S2
Mol. Mass.:
326.391
SMILES:
CN1C(=O)[C@]23CC4=CC=C[C@H](O)[C@H]4N2C(=O)[C@@]1(CO)SS3 |r,c:8,t:6,THB:12:13:1.2:19.20,15:14:1.2:19.20|
Structure:
Search PDB for entries with ligand similarity: