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Target
MAP kinase-interacting serine/threonine-protein kinase 2
Ligand
BDBM482160
Substrate
n/a
Meas. Tech.
ChEMBL_861407 (CHEMBL2173943)
IC50
600±n/a nM
Citation
 Choi, HG; Zhang, J; Deng, X; Hatcher, JM; Patricelli, MP; Zhao, Z; Alessi, DR; Gray, NS Brain Penetrant LRRK2 Inhibitor. ACS Med Chem Lett 3:658-662 (2012) [PubMed]  Article 
Target
Name:
MAP kinase-interacting serine/threonine-protein kinase 2
Synonyms:
GPRK7 | MAP kinase signal-integrating kinase 2 | MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2) | MAP kinase-interacting serine/threonine-protein kinase 2 (MnK2) | MAP-kinase interacting kinase 2 (MNK2) | MKNK2 | MKNK2_HUMAN | MNK2
Type:
Protein
Mol. Mass.:
51870.79
Organism:
Homo sapiens (Human)
Description:
Q9HBH9
Residue:
465
Sequence:
MVQKKPAELQGFHRSFKGQNPFELAFSLDQPDHGDSDFGLQCSARPDMPASQPIDIPDAKKRGKKKKRGRATDSFSGRFEDVYQLQEDVLGEGAHARVQTCINLITSQEYAVKIIEKQPGHIRSRVFREVEMLYQCQGHRNVLELIEFFEEEDRFYLVFEKMRGGSILSHIHKRRHFNELEASVVVQDVASALDFLHNKGIAHRDLKPENILCEHPNQVSPVKICDFDLGSGIKLNGDCSPISTPELLTPCGSAEYMAPEVVEAFSEEASIYDKRCDLWSLGVILYILLSGYPPFVGRCGSDCGWDRGEACPACQNMLFESIQEGKYEFPDKDWAHISCAAKDLISKLLVRDAKQRLSAAQVLQHPWVQGCAPENTLPTPMVLQRNSCAKDLTSFAAEAIAMNRQLAQHDEDLAEEEAAGQGQPVLVRATSRCLQLSPPSQSKLAQRRQRASLSSAPVVLVGDHA
  
Inhibitor
Name:
BDBM482160
Synonyms:
BDBM50396041 | HG-10-102-01
Type:
n/a
Emp. Form.:
C17H20ClN5O3
Mol. Mass.:
377.825
SMILES:
CNc1nc(Nc2ccc(cc2OC)C(=O)N2CCOCC2)ncc1Cl
Structure:
Search PDB for entries with ligand similarity: