Reaction Details
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17-beta-hydroxysteroid dehydrogenase type 2
Ligand
BDBM50396080
Substrate
n/a
Meas. Tech.
ChEMBL_861318 (CHEMBL2173706)
IC50
4003±n/a nM
Citation
Spadaro, A; Frotscher, M; Hartmann, RW Optimization of hydroxybenzothiazoles as novel potent and selective inhibitors of 17ß-HSD1. J Med Chem 55:2469-73 (2012) [PubMed] Article More Info.:
Target
Name:
17-beta-hydroxysteroid dehydrogenase type 2
Synonyms:
17-beta-Hydroxysteroid Dehydrogenase 2 (17-beta-HSD2) | 20 alpha-hydroxysteroid dehydrogenase | 20-alpha-HSD | DHB2_HUMAN | EDH17B2 | Estradiol 17-beta-dehydrogenase 2 | Estradiol 17-beta-dehydrogenase 2 (17beta-HSD2) | HSD17B2 | Microsomal 17-beta-hydroxysteroid dehydrogenas | SDR9C2 | Testosterone 17-beta-dehydrogenase
Type:
Oxidoreductase; single-pass type II membrane protein
Mol. Mass.:
42795.29
Organism:
Homo sapiens (Human)
Description:
Enzyme was partially purified from human placenta.
Residue:
387
Sequence:
MSTFFSDTAWICLAVPTVLCGTVFCKYKKSSGQLWSWMVCLAGLCAVCLLILSPFWGLILFSVSCFLMYTYLSGQELLPVDQKAVLVTGGDCGLGHALCKYLDELGFTVFAGVLNENGPGAEELRRTCSPRLSVLQMDITKPVQIKDAYSKVAAMLQDRGLWAVINNAGVLGFPTDGELLLMTDYKQCMAVNFFGTVEVTKTFLPLLRKSKGRLVNVSSMGGGAPMERLASYGSSKAAVTMFSSVMRLELSKWGIKVASIQPGGFLTNIAGTSDKWEKLEKDILDHLPAEVQEDYGQDYILAQRNFLLLINSLASKDFSPVLRDIQHAILAKSPFAYYTPGKGAYLWICLAHYLPIGIYDYFAKRHFGQDKPMPRALRMPNYKKKAT
Inhibitor
Name:
BDBM50396080
Synonyms:
CHEMBL2170754
Type:
Small organic molecule
Emp. Form.:
C15H11NO3S
Mol. Mass.:
285.318
SMILES:
Cc1ccc(cc1O)C(=O)c1nc2ccc(O)cc2s1
Structure:
