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Target
Oxysterols receptor LXR-beta
Ligand
BDBM50396605
Substrate
n/a
Meas. Tech.
ChEMBL_863932 (CHEMBL2176509)
IC50
15000±n/a nM
Citation
 Aoyama, A; Endo-Umeda, K; Kishida, K; Ohgane, K; Noguchi-Yachide, T; Aoyama, H; Ishikawa, M; Miyachi, H; Makishima, M; Hashimoto, Y Design, synthesis, and biological evaluation of novel transrepression-selective liver X receptor (LXR) ligands with 5,11-dihydro-5-methyl-11-methylene-6H-dibenz[b,e]azepin-6-one skeleton. J Med Chem 55:7360-77 (2012) [PubMed]  Article 
Target
Name:
Oxysterols receptor LXR-beta
Synonyms:
LXRB | Liver X receptor beta (NR1H2) | Liver X, LXR beta | NER | NR1H2 | NR1H2_HUMAN | Nuclear receptor NER | UNR | Ubiquitously-expressed nuclear receptor
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50978.79
Organism:
Homo sapiens (Human)
Description:
P55055
Residue:
460
Sequence:
MSSPTTSSLDTPLPGNGPPQPGAPSSSPTVKEEGPEPWPGGPDPDVPGTDEASSACSTDWVIPDPEEEPERKRKKGPAPKMLGHELCRVCGDKASGFHYNVLSCEGCKGFFRRSVVRGGARRYACRGGGTCQMDAFMRRKCQQCRLRKCKEAGMREQCVLSEEQIRKKKIRKQQQESQSQSQSPVGPQGSSSSASGPGASPGGSEAGSQGSGEGEGVQLTAAQELMIQQLVAAQLQCNKRSFSDQPKVTPWPLGADPQSRDARQQRFAHFTELAIISVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECITFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAINIFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVSLRTLSSVHSEQVFALRLQDKKLPPLLSEIWDVHE
  
Inhibitor
Name:
BDBM50396605
Synonyms:
CHEMBL2171829
Type:
Small organic molecule
Emp. Form.:
C26H23NO3
Mol. Mass.:
397.4657
SMILES:
CCc1ccc2N(C)C(=O)c3cc(ccc3C(=C)c2c1)-c1ccc(CC(O)=O)cc1
Structure:
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