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Target
Tyrosyl-DNA phosphodiesterase 1
Ligand
BDBM4301
Substrate
n/a
Meas. Tech.
ChEMBL_864727 (CHEMBL2174994)
IC50
>333000±n/a nM
Citation
 Sirivolu, VR; Vernekar, SK; Marchand, C; Naumova, A; Chergui, A; Renaud, A; Stephen, AG; Chen, F; Sham, YY; Pommier, Y; Wang, Z 5-Arylidenethioxothiazolidinones as inhibitors of tyrosyl-DNA phosphodiesterase I. J Med Chem 55:8671-84 (2012) [PubMed]  Article 
Target
Name:
Tyrosyl-DNA phosphodiesterase 1
Synonyms:
TDP1 | TYDP1_HUMAN | Tyrosyl-DNA phosphodiesterase 1 | Tyrosyl-DNA phosphodiesterase 1 (TDP1)
Type:
Enzyme
Mol. Mass.:
68430.66
Organism:
Homo sapiens (Human)
Description:
Q9NUW8
Residue:
608
Sequence:
MSQEGDYGRWTISSSDESEEEKPKPDKPSTSSLLCARQGAANEPRYTCSEAQKAAHKRKISPVKFSNTDSVLPPKRQKSGSQEDLGWCLSSSDDELQPEMPQKQAEKVVIKKEKDISAPNDGTAQRTENHGAPACHRLKEEEDEYETSGEGQDIWDMLDKGNPFQFYLTRVSGVKPKYNSGALHIKDILSPLFGTLVSSAQFNYCFDVDWLVKQYPPEFRKKPILLVHGDKREAKAHLHAQAKPYENISLCQAKLDIAFGTHHTKMMLLLYEEGLRVVIHTSNLIHADWHQKTQGIWLSPLYPRIADGTHKSGESPTHFKADLISYLMAYNAPSLKEWIDVIHKHDLSETNVYLIGSTPGRFQGSQKDNWGHFRLKKLLKDHASSMPNAESWPVVGQFSSVGSLGADESKWLCSEFKESMLTLGKESKTPGKSSVPLYLIYPSVENVRTSLEGYPAGGSLPYSIQTAEKQNWLHSYFHKWSAETSGRSNAMPHIKTYMRPSPDFSKIAWFLVTSANLSKAAWGALEKNGTQLMIRSYELGVLFLPSAFGLDSFKVKQKFFAGSQEPMATFPVPYDLPPELYGSKDRPWIWNIPYVKAPDTHGNMWVPS
  
Inhibitor
Name:
BDBM4301
Synonyms:
(2E)-2-cyano-3-(3,4-dihydroxyphenyl)prop-2-enamide | CHEMBL296407 | Tyrphostin deriv. 40 | benzylidenemalononitrile (BMN) deriv. 46
Type:
Small organic molecule
Emp. Form.:
C10H8N2O3
Mol. Mass.:
204.1821
SMILES:
NC(=O)C(=C\c1ccc(O)c(O)c1)\C#N
Structure:
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