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Target
Scavenger receptor class B member 1
Ligand
BDBM50397870
Substrate
n/a
Meas. Tech.
ChEMBL_872680 (CHEMBL2184660)
IC50
1.5±n/a nM
Citation
 Mittapalli, GK; Zhao, F; Jackson, A; Gao, H; Lee, H; Chow, S; Kaur, MP; Nguyen, N; Zamboni, R; McKelvy, J; Wong-Staal, F; Macdonald, JE Discovery of ITX 4520: a highly potent orally bioavailable hepatitis C virus entry inhibitor. Bioorg Med Chem Lett 22:4955-61 (2012) [PubMed]  Article 
Target
Name:
Scavenger receptor class B member 1
Synonyms:
CD36 and LIMPII analogous 1 | CD36 antigen-like 1 | CD36L1 | CD_antigen=CD36 | CLA-1 | CLA1 | Collagen type I receptor, thrombospondin receptor-like 1 | SCARB1 | SCRB1_HUMAN | SR-BI | SRB1
Type:
PROTEIN
Mol. Mass.:
60889.81
Organism:
Homo sapiens (Human)
Description:
ChEMBL_872680
Residue:
552
Sequence:
MGCSAKARWAAGALGVAGLLCAVLGAVMIVMVPSLIKQQVLKNVRIDPSSLSFNMWKEIPIPFYLSVYFFDVMNPSEILKGEKPQVRERGPYVYREFRHKSNITFNNNDTVSFLEYRTFQFQPSKSHGSESDYIVMPNILVLGAAVMMENKPMTLKLIMTLAFTTLGERAFMNRTVGEIMWGYKDPLVNLINKYFPGMFPFKDKFGLFAELNNSDSGLFTVFTGVQNISRIHLVDKWNGLSKVDFWHSDQCNMINGTSGQMWPPFMTPESSLEFYSPEACRSMKLMYKESGVFEGIPTYRFVAPKTLFANGSIYPPNEGFCPCLESGIQNVSTCRFSAPLFLSHPHFLNADPVLAEAVTGLHPNQEAHSLFLDIHPVTGIPMNCSVKLQLSLYMKSVAGIGQTGKIEPVVLPLLWFAESGAMEGETLHTFYTQLVLMPKVMHYAQYVLLALGCVLLLVPVICQIRSQVGAGQRAARADSHSLACWGKGASDRTLWPTAAWSPPPAAVLRLCRSGSGHCWGLRSTLASFACRVATTLPVLEGLGPSLGGGTGS
  
Inhibitor
Name:
BDBM50397870
Synonyms:
CHEMBL2179501
Type:
Small organic molecule
Emp. Form.:
C24H24F3N5O2
Mol. Mass.:
471.4749
SMILES:
Cc1noc(n1)-c1ccc2n(CCCOc3nc(C)cc(n3)C(F)(F)F)c3CCCCc3c2c1
Structure:
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