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Target
Cathepsin D
Ligand
BDBM50398285
Substrate
n/a
Meas. Tech.
ChEMBL_874924 (CHEMBL2183109)
IC50
12600±n/a nM
Citation
 Huang, H; La, DS; Cheng, AC; Whittington, DA; Patel, VF; Chen, K; Dineen, TA; Epstein, O; Graceffa, R; Hickman, D; Kiang, YH; Louie, S; Luo, Y; Wahl, RC; Wen, PH; Wood, S; Fremeau, RT Structure- and property-based design of aminooxazoline xanthenes as selective, orally efficacious, and CNS penetrable BACE inhibitors for the treatment of Alzheimer's disease. J Med Chem 55:9156-69 (2012) [PubMed]  Article 
Target
Name:
Cathepsin D
Synonyms:
CATD_HUMAN | CPSD | CTSD | Cathepsin D [Precursor] | Cathepsin D heavy chain | Cathepsin D light chain | Cathepsin D precursor
Type:
Enzyme
Mol. Mass.:
44551.72
Organism:
Homo sapiens (Human)
Description:
Human proCathepsin D (SwissProt accession number P07339) was expressed in Sf9 cells, purified, and autoactivated.
Residue:
412
Sequence:
MQPSSLLPLALCLLAAPASALVRIPLHKFTSIRRTMSEVGGSVEDLIAKGPVSKYSQAVPAVTEGPIPEVLKNYMDAQYYGEIGIGTPPQCFTVVFDTGSSNLWVPSIHCKLLDIACWIHHKYNSDKSSTYVKNGTSFDIHYGSGSLSGYLSQDTVSVPCQSASSASALGGVKVERQVFGEATKQPGITFIAAKFDGILGMAYPRISVNNVLPVFDNLMQQKLVDQNIFSFYLSRDPDAQPGGELMLGGTDSKYYKGSLSYLNVTRKAYWQVHLDQVEVASGLTLCKEGCEAIVDTGTSLMVGPVDEVRELQKAIGAVPLIQGEYMIPCEKVSTLPAITLKLGGKGYKLSPEDYTLKVSQAGKTLCLSGFMGMDIPPPSGPLWILGDVFIGRYYTVFDRDNNRVGFAEAARL
  
Inhibitor
Name:
BDBM50398285
Synonyms:
CHEMBL2177315
Type:
Small organic molecule
Emp. Form.:
C21H18FN3O2
Mol. Mass.:
363.3849
SMILES:
COc1ccc(cc1)C1(COC(N)=N1)c1cccc(c1)-c1cccnc1F |c:13|
Structure:
Search PDB for entries with ligand similarity: