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Target
Glucose-dependent insulinotropic receptor
Ligand
BDBM50400369
Substrate
n/a
Meas. Tech.
ChEMBL_877428 (CHEMBL2183225)
EC50
398.11±n/a nM
Citation
 Katamreddy, SR; Carpenter, AJ; Ammala, CE; Boros, EE; Brashear, RL; Briscoe, CP; Bullard, SR; Caldwell, RD; Conlee, CR; Croom, DK; Hart, SM; Heyer, DO; Johnson, PR; Kashatus, JA; Minick, DJ; Peckham, GE; Ross, SA; Roller, SG; Samano, VA; Sauls, HR; Tadepalli, SM; Thompson, JB; Xu, Y; Way, JM Discovery of 6,7-dihydro-5H-pyrrolo[2,3-a]pyrimidines as orally available G protein-coupled receptor 119 agonists. J Med Chem 55:10972-94 (2012) [PubMed]  Article 
Target
Name:
Glucose-dependent insulinotropic receptor
Synonyms:
G-protein coupled receptor 119 (GPR119) | GP119_HUMAN | GPR119 | Glucose-dependent insulinotropic receptor
Type:
Protein
Mol. Mass.:
36901.49
Organism:
Homo sapiens (Human)
Description:
Q8TDV5
Residue:
335
Sequence:
MESSFSFGVILAVLASLIIATNTLVAVAVLLLIHKNDGVSLCFTLNLAVADTLIGVAISGLLTDQLSSPSRPTQKTLCSLRMAFVTSSAAASVLTVMLITFDRYLAIKQPFRYLKIMSGFVAGACIAGLWLVSYLIGFLPLGIPMFQQTAYKGQCSFFAVFHPHFVLTLSCVGFFPAMLLFVFFYCDMLKIASMHSQQIRKMEHAGAMAGGYRSPRTPSDFKALRTVSVLIGSFALSWTPFLITGIVQVACQECHLYLVLERYLWLLGVGNSLLNPLIYAYWQKEVRLQLYHMALGVKKVLTSFLLFLSARNCGPERPRESSCHIVTISSSEFDG
  
Inhibitor
Name:
BDBM50400369
Synonyms:
CHEMBL2181686
Type:
Small organic molecule
Emp. Form.:
C22H24FN5O3
Mol. Mass.:
425.4561
SMILES:
CC(C)OC(=O)N1CCC(CC1)Oc1ncnc2N(CCc12)c1ccc(C#N)c(F)c1
Structure:
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