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Target
DnaJ homolog subfamily A member 1
Ligand
BDBM50139187
Substrate
n/a
Meas. Tech.
ChEMBL_879211 (CHEMBL2208524)
EC50
12±n/a nM
Citation
 Marsault, E; Peterson, ML Macrocycles are great cycles: applications, opportunities, and challenges of synthetic macrocycles in drug discovery. J Med Chem 54:1961-2004 (2011) [PubMed]  Article 
Target
Name:
DnaJ homolog subfamily A member 1
Synonyms:
DNAJ2 | DNAJA1 | DNJA1_HUMAN | DnaJ protein homolog 2 | HDJ2 | HSDJ | HSJ-2 | HSJ2 | HSPF4 | Heat shock 40 kDa protein 4 | Heat shock protein J2 | Human DnaJ protein 2 | hDj-2
Type:
PROTEIN
Mol. Mass.:
44871.75
Organism:
Homo sapiens (Human)
Description:
ChEMBL_879211
Residue:
397
Sequence:
MVKETTYYDVLGVKPNATQEELKKAYRKLALKYHPDKNPNEGEKFKQISQAYEVLSDAKKRELYDKGGEQAIKEGGAGGGFGSPMDIFDMFFGGGGRMQRERRGKNVVHQLSVTLEDLYNGATRKLALQKNVICDKCEGRGGKKGAVECCPNCRGTGMQIRIHQIGPGMVQQIQSVCMECQGHGERISPKDRCKSCNGRKIVREKKILEVHIDKGMKDGQKITFHGEGDQEPGLEPGDIIIVLDQKDHAVFTRRGEDLFMCMDIQLVEALCGFQKPISTLDNRTIVITSHPGQIVKHGDIKCVLNEGMPIYRRPYEKGRLIIEFKVNFPENGFLSPDKLSLLEKLLPERKEVEETDEMDQVELVDFDPNQERRRHYNGEAYEDDEHHPRGGVQCQTS
  
Inhibitor
Name:
BDBM50139187
Synonyms:
4-(2-cyclohexylethyl)-23-oxo-8-oxa-1,15,17,21-tetraazapentacyclo[19.2.2.13,7.19,13.015,19]heptacosa-3(27),4,6,9(26),10,12,16,18-octaen-10-yl cyanide | CHEMBL159171
Type:
Small organic molecule
Emp. Form.:
C31H35N5O2
Mol. Mass.:
509.6419
SMILES:
O=C1CN2CCN1Cc1cc(Oc3cc(Cn4cncc4C2)ccc3C#N)ccc1CCC1CCCCC1
Structure:
Search PDB for entries with ligand similarity: