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Target
Protein phosphatase methylesterase 1
Ligand
BDBM50400991
Substrate
n/a
Meas. Tech.
ChEMBL_879621 (CHEMBL2209153)
IC50
6800±n/a nM
Citation
 Bachovchin, DA; Zuhl, AM; Speers, AE; Wolfe, MR; Weerapana, E; Brown, SJ; Rosen, H; Cravatt, BF Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1. J Med Chem 54:5229-36 (2011) [PubMed]  Article 
Target
Name:
Protein phosphatase methylesterase 1
Synonyms:
PME-1 | PPME1_MOUSE | Pme1 | Ppme1
Type:
PROTEIN
Mol. Mass.:
42251.88
Organism:
Mus musculus
Description:
ChEMBL_879621
Residue:
386
Sequence:
MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFTPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRGHGETKVKNSEDLSAETMAKDVGNVVEAMYGDLPPPVMLIGHSMGGAIAVHTAAANLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESVNKRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC
  
Inhibitor
Name:
BDBM50400991
Synonyms:
CHEMBL1711185
Type:
Small organic molecule
Emp. Form.:
C17H18N2O4S2
Mol. Mass.:
378.466
SMILES:
CC(C)(C)S(=O)(=O)C(=C\c1cccn1S(=O)(=O)c1ccccc1)\C#N
Structure:
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