Reaction Details Report a problem with these data
Target
Signal transducer and transcription activator 6
Ligand
BDBM50401026
Substrate
n/a
Meas. Tech.
ChEMBL_881632 (CHEMBL2216405)
IC50
2740±n/a nM
Citation
 Zhou, L; Kawate, T; Liu, X; Kim, YB; Zhao, Y; Feng, G; Banerji, J; Nash, H; Whitehurst, C; Jindal, S; Siddiqui, A; Seed, B; Wolfe, JL STAT6 phosphorylation inhibitors block eotaxin-3 secretion in bronchial epithelial cells. Bioorg Med Chem 20:750-8 (2012) [PubMed]  Article 
Target
Name:
Signal transducer and transcription activator 6
Synonyms:
STAT6_MOUSE | Stat6
Type:
PROTEIN
Mol. Mass.:
93492.57
Organism:
Mus musculus
Description:
ChEMBL_881632
Residue:
837
Sequence:
MSLWGLISKMSPEKLQRLYVDFPQRLRHLLADWLESQPWEFLVGSDAFCYNMASALLSATVQRLQATAGEQGKGNSILPHISTLESIYQRDPLKLVATIRQILQGEKKAVIEEFRHLPGPFHRKQEELKFTTALGRLQHRVRETRLLRESLQQGAKTGQVSLQNLIDPPVNGPGPSEDLATMLQGTVGDLEATQALVLKRIQIWKRQQQLAGNGTPFEESLAGLQERCESLVEIYSQLQQEIGAASGELEPKTRASLISRLDEVLRTLVTSSFLVEKQPPQVLKTQTKFQAGVRFLLGLQFLGTSAKPPMVRADMVTEKQARELSLAQGPGTGVESTGEIMNNTVPLENSIPSNCCSALFKNLLLKKIKRCERKGTESVTEEKCAVLFSTSFTLGPNKLLIQLQALSLPLVVIVHGNQDNNAKATILWDNAFSEMDRVPFVVAERVPWEKMCETLNLKFMAEVGTSRGLLPEHFLFLAQKIFNDNSLSVEAFQHRCVSWSQFNKEILLGRGFTFWQWFDGVLDLTKRCLRSYWSDRLIIGFISKQYVTSLLLNEPDGTFLLRFSDSEIGGITIAHVIRGQDGSSQIENIQPFSAKDLSIRSLGDRIRDLAQLKNLYPKKPKDEAFRSHYKPEQMGKDGRGYVSTTIKMTVERDQPLPTPEPQMPAMVPPYDLGMAPDASMQLSSDMGYPPQSIHSFQSLEESMSVLPSFQEPHLQMPPNMSQITMPFDQPHPQGLLQCQSQEHAVSSPEPMLCSDVTMVEDSCLTQPVGGFPQGTWVSEDMYPPLMPPTEQDLTKLLLENQGEAGGSLGSQPLLQPSPYGQSGISLSHLDLRTNPSW
  
Inhibitor
Name:
BDBM50401026
Synonyms:
CHEMBL2204367
Type:
Small organic molecule
Emp. Form.:
C28H31N5O2
Mol. Mass.:
469.578
SMILES:
CC(C)[C@@H](C)NC(=O)c1cc(cc(n1)C(=O)NCCc1ccccn1)-c1cc2ccccc2n1C |r|
Structure:
Search PDB for entries with ligand similarity: