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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50402299
Substrate
n/a
Meas. Tech.
ChEMBL_885616 (CHEMBL2211288)
IC50
200±n/a nM
Citation
 Cheung, AW; Banner, B; Bose, J; Kim, K; Li, S; Marcopulos, N; Orzechowski, L; Sergi, JA; Thakkar, KC; Wang, BB; Yun, W; Zwingelstein, C; Berthel, S; Olivier, AR 7-Phenyl-pyrido[2,3-d]pyrimidine-2,4-diamines: novel and highly selective protein tyrosine phosphatase 1B inhibitors. Bioorg Med Chem Lett 22:7518-22 (2012) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50402299
Synonyms:
CHEMBL2206064
Type:
Small organic molecule
Emp. Form.:
C21H16F3N5O
Mol. Mass.:
411.3798
SMILES:
CNc1nc(N)nc2nc(ccc12)-c1c(Oc2ccccc2)cccc1C(F)(F)F
Structure:
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