Reaction Details Report a problem with these data
Target
Growth hormone-releasing hormone receptor
Ligand
BDBM50403616
Substrate
n/a
Meas. Tech.
ChEBML_193173
EC50
2.3±n/a nM
Citation
 Tata, JR; Lu, Z; Jacks, TM; Schleim, KD; Cheng, K; Wei, L; Chan, WW; Butler, B; Tsou, N; Leung, K; Chiu, S; Hickey, G; Smith, RG; Patchett, AA The design and synthesis of orally active short duration spiroindane growth hormone secretagogues Bioorg Med Chem Lett 7:2319-2324 (1997)    Article 
Target
Name:
Growth hormone-releasing hormone receptor
Synonyms:
GHRH receptor | GHRHR_RAT | GRF receptor | Ghrhr | Grfr
Type:
PROTEIN
Mol. Mass.:
51523.38
Organism:
Rattus norvegicus
Description:
ChEMBL_193173
Residue:
464
Sequence:
MDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
  
Inhibitor
Name:
BDBM50403616
Synonyms:
CHEMBL540805
Type:
Small organic molecule
Emp. Form.:
C30H39N3O4
Mol. Mass.:
505.6484
SMILES:
CC(C)(N)C(=O)N[C@H](CCCc1ccccc1)C(=O)N1CCC2(C[C@H](CC(O)=O)c3ccccc23)CC1 |r|
Structure:
Search PDB for entries with ligand similarity: