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Target
Growth hormone-releasing hormone receptor
Ligand
BDBM50403625
Substrate
n/a
Meas. Tech.
ChEBML_193173
EC50
0.800000±n/a nM
Citation
 Tata, JR; Lu, Z; Jacks, TM; Schleim, KD; Cheng, K; Wei, L; Chan, WW; Butler, B; Tsou, N; Leung, K; Chiu, S; Hickey, G; Smith, RG; Patchett, AA The design and synthesis of orally active short duration spiroindane growth hormone secretagogues Bioorg Med Chem Lett 7:2319-2324 (1997)    Article 
Target
Name:
Growth hormone-releasing hormone receptor
Synonyms:
GHRH receptor | GHRHR_RAT | GRF receptor | Ghrhr | Grfr
Type:
PROTEIN
Mol. Mass.:
51523.38
Organism:
Rattus norvegicus
Description:
ChEMBL_193173
Residue:
464
Sequence:
MDSLLWATWVLCLLNLWGVALGHLHLECDFITQLRDDELACLQAAEGTNNSSMGCPGTWDGLLCWPPTGSGQWVSLPCPEFFSHFGSDPGAVKRDCTITGWSDPFPPYPVACPVPLELLTEEKSYFSTVKIIYTTGHSISIVALCVAIAILVALRRLHCPRNYIHTQLFATFILKASAVFLKDAAVFQGDSTDHCSMSTILCKVSVAVSHFATMTNFSWLLAEAVYLSCLLASTSPRSKPAFWWLVLAGWGLPVLCTGTWVGCKLAFEDTACWDLDDSSPYWWIIKGPIVLSVGVNFGLFLNIICILLRKLGPAQGGLHTRAQYCNYLLPWSCPLPQVPRERTDLGPSSHEITVQESGTRNCQLPWRLSKSTLLLIPLFGIHYIIFNFLPDSAGLGIRLPLELGLGSFQGFVVAVLYCFLNQEVRTEISRKWYGHDPELLPARRTCTEWTTPPRSRVKVLTSEC
  
Inhibitor
Name:
BDBM50403625
Synonyms:
CHEMBL545002
Type:
Small organic molecule
Emp. Form.:
C32H43N3O4
Mol. Mass.:
533.7015
SMILES:
CCOC(=O)C[C@@H]1CC2(CCN(CC2)C(=O)[C@@H](CCCc2ccccc2)NC(=O)C(C)(C)N)c2ccccc12 |r|
Structure:
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