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Target
Histidine-rich protein PFHRP-II
Ligand
BDBM50102932
Substrate
n/a
Meas. Tech.
ChEBML_155105
IC50
97000±n/a nM
Citation
 Ayad, F; Tilley, L; Deady, LW Synthesis, antimalarial activity and inhibition of haem detoxification of novel bisquinolines. Bioorg Med Chem Lett 11:2075-7 (2001) [PubMed]  Article 
Target
Name:
Histidine-rich protein PFHRP-II
Synonyms:
HRP1_PLAFA | Histidine-rich protein | Histidine-rich protein PFHRP-II
Type:
PROTEIN
Mol. Mass.:
35156.49
Organism:
Plasmodium falciparum
Description:
ChEMBL_500704
Residue:
332
Sequence:
MVSFSKNKVLSAAVFASVLLLDNNNSAFNNNLCSKNAKGLNLNKRLLHETQAHVDDAHHAHHVADAHHAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAADAHHAHHAAYAHHAHHASDAHHAADAHHAAYAHHAHHAADAHHAADAHHAAYAHHAHHAADAHHAADAHHATDAHHAHHAADAHHATDAHHAADAHHAADAHHATDAHHAADAHHATDAHHAADAHHAADAHHATDSHHAHHAADAHHAAAHHATDAHHAAAHHATDAHHAAAHHEAATHCLRH
  
Inhibitor
Name:
BDBM50102932
Synonyms:
CHEMBL62603 | N*4*-(2-{8-[4-(4-Diethylamino-1-methyl-butylamino)-quinolin-2-yl]-octyl}-quinolin-4-yl)-N*1*,N*1*-diethyl-pentane-1,4-diamine | N4,N4'-(2,2'-(octane-1,8-diyl)bis(quinoline-4,2-diyl))bis(N1,N1-diethylpentane-1,4-diamine)
Type:
Small organic molecule
Emp. Form.:
C44H68N6
Mol. Mass.:
681.0509
SMILES:
CCN(CC)CCCC(C)Nc1cc(CCCCCCCCc2cc(NC(C)CCCN(CC)CC)c3ccccc3n2)nc2ccccc12
Structure:
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