Reaction Details Report a problem with these data
Target
Malate dehydrogenase, mitochondrial
Ligand
BDBM50404724
Substrate
n/a
Meas. Tech.
ChEMBL_123822 (CHEMBL733653)
IC50
4786.3±n/a nM
Citation
 Coats, EA; Shah, KJ; Milstein, SR; Genther, CS; Nene, DM; Roesener, J; Schmidt, J; Pleiss, M; Wagner, E; Baker, JK 4-hydroxyquinoline-3-carboxylic acids as inhibitors of cell respiration. 2. Quantitative structure-activity relationship of dehydrogenase enzyme and Ehrlich ascites tumor cell inhibitions. J Med Chem 25:57-63 (1982) [PubMed]  Article 
Target
Name:
Malate dehydrogenase, mitochondrial
Synonyms:
MDH2 | MDHM_PIG | Malate dehydrogenase mitochondrial
Type:
Oxidoreductase; homodimer
Mol. Mass.:
35493.48
Organism:
Sus scrofa (pig)
Description:
Porcine heart mitochondria.
Residue:
337
Sequence:
MLSALARPAGAALRRSFSTSQNNAKVAVLGASGGIGQPLSLLLKNSPLVSRLTLYDIAHTPGVAADLSHIETRATVKGYLGPEQLPDCLKGCDVVVIPAGVPRKPGMTRDDLFNTNATIVATLTAACAQHCPDAMICIISNPVNSTIPITAEVFKKHGVYNPNKIFGVTTLDIVRANAFVAELKGLDPARVSVPVIGGHAGKTIIPLISQCTPKVDFPQDQLSTLTGRIQEAGTEVVKAKAGAGSATLSMAYAGARFVFSLVDAMNGKEGVVECSFVKSQETDCPYFSTPLLLGKKGIEKNLGIGKISPFEEKMIAEAIPELKASIKKGEEFVKNMK
  
Inhibitor
Name:
BDBM50404724
Synonyms:
CHEMBL156108
Type:
Small organic molecule
Emp. Form.:
C17H8Cl5NO4
Mol. Mass.:
467.515
SMILES:
OC(=O)c1cnc2cc(OCc3c(Cl)c(Cl)c(Cl)c(Cl)c3Cl)ccc2c1O
Structure:
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