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Target
Lutropin-choriogonadotropic hormone receptor
Ligand
BDBM50405772
Substrate
n/a
Meas. Tech.
ChEMBL_100146 (CHEMBL712503)
Ki
1.4±n/a nM
Citation
 Haviv, F; Palabrica, CA; Bush, EN; Diaz, G; Johnson, ES; Love, S; Greer, J Active reduced-size hexapeptide analogues of luteinizing hormone-releasing hormone. J Med Chem 32:2340-4 (1989) [PubMed]  Article 
Target
Name:
Lutropin-choriogonadotropic hormone receptor
Synonyms:
LH/CG-R | LSH-R | LSHR_RAT | Lhcgr | Luteinizing hormone receptor | Luteinizing hormone/Choriogonadotropin receptor | Lutropin-choriogonadotropic hormone receptor
Type:
PROTEIN
Mol. Mass.:
78049.26
Organism:
Rattus norvegicus
Description:
ChEMBL_97289
Residue:
700
Sequence:
MGRRVPALRQLLVLAVLLLKPSQLQSRELSGSRCPEPCDCAPDGALRCPGPRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSELLIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMHSGAFQGATGPSILDISSTKLQALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSIFENFSKQCESTVRKADNETLYSAIFEENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILILNVVAFVVICACYIRIYFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEFSAYTSNCKNGFPGASKPSQATLKLSTVHCQQPIPPRALTH
  
Inhibitor
Name:
BDBM50405772
Synonyms:
CHEMBL2369787
Type:
Small organic molecule
Emp. Form.:
C52H69N11O10
Mol. Mass.:
1008.172
SMILES:
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)\C=C/c1ccc(OC)cc1 |wU:5.4,31.32,45.48,23.24,wD:57.61,12.13,(32.43,-18.06,;30.96,-17.65,;30.57,-16.16,;29.09,-15.76,;27.98,-16.85,;28.68,-14.27,;29.66,-13.08,;28.83,-11.78,;27.33,-12.17,;27.24,-13.7,;25.92,-12.93,;25.94,-11.4,;24.6,-13.7,;24.58,-15.24,;25.89,-16.05,;25.86,-17.57,;27.21,-18.35,;27.17,-19.89,;25.85,-20.65,;28.51,-20.68,;23.25,-12.92,;21.91,-13.7,;21.95,-15.24,;20.59,-12.96,;20.57,-11.4,;21.88,-10.63,;23.23,-11.38,;21.88,-9.09,;19.25,-13.74,;17.91,-12.97,;17.91,-11.43,;16.59,-13.76,;16.59,-15.3,;17.94,-16.05,;19.35,-15.43,;20.37,-16.56,;19.63,-17.89,;20.12,-19.37,;19.09,-20.5,;17.57,-20.21,;17.09,-18.74,;18.1,-17.58,;15.24,-13,;13.92,-13.77,;13.93,-15.31,;12.55,-13.02,;12.55,-11.46,;13.89,-10.69,;15.23,-11.45,;16.56,-10.66,;16.55,-9.12,;17.87,-8.35,;15.21,-8.37,;13.86,-9.15,;11.24,-13.8,;9.89,-13.03,;9.89,-11.49,;8.57,-13.83,;8.57,-15.36,;9.92,-16.11,;7.23,-13.06,;5.88,-13.83,;5.91,-15.39,;4.55,-13.08,;3.22,-13.86,;3.22,-15.4,;4.56,-16.14,;4.56,-17.68,;3.24,-18.47,;3.25,-19.99,;4.59,-20.76,;1.9,-17.71,;1.9,-16.17,)|
Structure:
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