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Target
Lutropin-choriogonadotropic hormone receptor
Ligand
BDBM50405768
Substrate
n/a
Meas. Tech.
ChEMBL_100146 (CHEMBL712503)
Ki
1349±n/a nM
Citation
 Haviv, F; Palabrica, CA; Bush, EN; Diaz, G; Johnson, ES; Love, S; Greer, J Active reduced-size hexapeptide analogues of luteinizing hormone-releasing hormone. J Med Chem 32:2340-4 (1989) [PubMed]  Article 
Target
Name:
Lutropin-choriogonadotropic hormone receptor
Synonyms:
LH/CG-R | LSH-R | LSHR_RAT | Lhcgr | Luteinizing hormone receptor | Luteinizing hormone/Choriogonadotropin receptor | Lutropin-choriogonadotropic hormone receptor
Type:
PROTEIN
Mol. Mass.:
78049.26
Organism:
Rattus norvegicus
Description:
ChEMBL_97289
Residue:
700
Sequence:
MGRRVPALRQLLVLAVLLLKPSQLQSRELSGSRCPEPCDCAPDGALRCPGPRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSELLIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMHSGAFQGATGPSILDISSTKLQALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSIFENFSKQCESTVRKADNETLYSAIFEENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILILNVVAFVVICACYIRIYFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEFSAYTSNCKNGFPGASKPSQATLKLSTVHCQQPIPPRALTH
  
Inhibitor
Name:
BDBM50405768
Synonyms:
CHEMBL2369790
Type:
Small organic molecule
Emp. Form.:
C47H69N11O9
Mol. Mass.:
932.1191
SMILES:
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)Cc1c[nH]c2ccccc12 |wU:5.4,39.40,23.24,31.32,wD:51.53,12.13,(33.09,-17.97,;31.6,-17.58,;31.21,-16.08,;29.74,-15.69,;28.64,-16.77,;29.34,-14.18,;30.31,-13,;29.48,-11.72,;27.97,-12.1,;27.9,-13.64,;26.58,-12.87,;26.59,-11.33,;25.25,-13.64,;25.22,-15.18,;26.55,-15.97,;26.53,-17.51,;27.84,-18.29,;27.83,-19.83,;26.5,-20.57,;29.16,-20.6,;23.9,-12.84,;22.58,-13.64,;22.59,-15.18,;21.24,-12.87,;21.21,-11.33,;22.54,-10.56,;23.89,-11.3,;22.52,-9.02,;19.91,-13.66,;18.57,-12.9,;18.55,-11.36,;17.23,-13.67,;17.25,-15.21,;18.58,-15.98,;19.86,-15.11,;18.76,-17.51,;15.88,-12.92,;14.57,-13.7,;14.57,-15.24,;13.21,-12.93,;13.21,-11.39,;14.54,-10.59,;14.53,-9.07,;15.85,-8.28,;17.2,-9.05,;18.51,-8.27,;17.22,-10.59,;15.88,-11.36,;11.9,-13.72,;10.55,-12.97,;10.53,-11.43,;9.21,-13.76,;9.24,-15.27,;10.56,-16.04,;7.89,-12.99,;6.54,-13.77,;6.55,-15.31,;5.21,-13,;3.88,-13.79,;3.76,-15.33,;2.29,-15.69,;1.45,-14.4,;-.03,-14.12,;-.57,-12.7,;.43,-11.51,;1.93,-11.78,;2.45,-13.22,)|
Structure:
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