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Target
Lutropin-choriogonadotropic hormone receptor
Ligand
BDBM50405781
Substrate
n/a
Meas. Tech.
ChEMBL_100146 (CHEMBL712503)
Ki
4.7±n/a nM
Citation
 Haviv, F; Palabrica, CA; Bush, EN; Diaz, G; Johnson, ES; Love, S; Greer, J Active reduced-size hexapeptide analogues of luteinizing hormone-releasing hormone. J Med Chem 32:2340-4 (1989) [PubMed]  Article 
Target
Name:
Lutropin-choriogonadotropic hormone receptor
Synonyms:
LH/CG-R | LSH-R | LSHR_RAT | Lhcgr | Luteinizing hormone receptor | Luteinizing hormone/Choriogonadotropin receptor | Lutropin-choriogonadotropic hormone receptor
Type:
PROTEIN
Mol. Mass.:
78049.26
Organism:
Rattus norvegicus
Description:
ChEMBL_97289
Residue:
700
Sequence:
MGRRVPALRQLLVLAVLLLKPSQLQSRELSGSRCPEPCDCAPDGALRCPGPRAGLARLSLTYLPVKVIPSQAFRGLNEVVKIEISQSDSLERIEANAFDNLLNLSELLIQNTKNLLYIEPGAFTNLPRLKYLSICNTGIRTLPDVTKISSSEFNFILEICDNLHITTIPGNAFQGMNNESVTLKLYGNGFEEVQSHAFNGTTLISLELKENIYLEKMHSGAFQGATGPSILDISSTKLQALPSHGLESIQTLIALSSYSLKTLPSKEKFTSLLVATLTYPSHCCAFRNLPKKEQNFSFSIFENFSKQCESTVRKADNETLYSAIFEENELSGWDYDYGFCSPKTLQCAPEPDAFNPCEDIMGYAFLRVLIWLINILAIFGNLTVLFVLLTSRYKLTVPRFLMCNLSFADFCMGLYLLLIASVDSQTKGQYYNHAIDWQTGSGCGAAGFFTVFASELSVYTLTVITLERWHTITYAVQLDQKLRLRHAIPIMLGGWLFSTLIATMPLVGISNYMKVSICLPMDVESTLSQVYILSILILNVVAFVVICACYIRIYFAVQNPELTAPNKDTKIAKKMAILIFTDFTCMAPISFFAISAAFKVPLITVTNSKILLVLFYPVNSCANPFLYAIFTKAFQRDFLLLLSRFGCCKRRAELYRRKEFSAYTSNCKNGFPGASKPSQATLKLSTVHCQQPIPPRALTH
  
Inhibitor
Name:
BDBM50405781
Synonyms:
CHEMBL2369814
Type:
Small organic molecule
Emp. Form.:
C53H71N13O9
Mol. Mass.:
1034.2125
SMILES:
CCNC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CO)NC(=O)[C@@H](N)Cc1c[nH]c2ccccc12 |wU:5.4,31.32,63.68,45.48,23.24,wD:57.61,12.13,(30.12,-15.49,;28.62,-15.1,;28.24,-13.6,;26.76,-13.21,;25.66,-14.29,;26.37,-11.71,;27.34,-10.52,;26.51,-9.24,;25,-9.62,;24.93,-11.16,;23.61,-10.39,;23.62,-8.85,;22.28,-11.16,;22.25,-12.7,;23.58,-13.49,;23.56,-15.03,;24.87,-15.81,;24.86,-17.34,;23.53,-18.08,;26.19,-18.11,;20.93,-10.36,;19.61,-11.16,;19.62,-12.7,;18.27,-10.39,;18.24,-8.85,;19.58,-8.08,;19.56,-6.55,;20.92,-8.82,;16.95,-11.18,;15.6,-10.42,;15.58,-8.89,;14.27,-11.19,;14.29,-12.73,;15.61,-13.5,;17.02,-12.86,;18.07,-14,;17.31,-15.33,;17.79,-16.8,;16.77,-17.95,;15.26,-17.65,;14.78,-16.19,;15.8,-15.03,;12.92,-10.42,;11.61,-11.22,;11.61,-12.76,;10.25,-10.46,;10.25,-8.92,;11.58,-8.14,;11.57,-6.6,;12.89,-5.81,;14.24,-6.58,;15.55,-5.8,;14.26,-8.12,;12.92,-8.89,;8.94,-11.22,;7.59,-10.49,;7.57,-8.95,;6.26,-11.28,;6.26,-12.79,;7.6,-13.56,;4.93,-10.51,;3.59,-11.29,;3.6,-12.83,;2.25,-10.52,;.93,-11.31,;2.24,-8.98,;.91,-8.23,;-.51,-8.85,;-1.56,-7.73,;-.79,-6.39,;-1.27,-4.91,;-.25,-3.76,;1.26,-4.08,;1.74,-5.54,;.72,-6.71,)|
Structure:
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