Reaction Details Report a problem with these data
Target
Histamine H1 receptor
Ligand
BDBM50131441
Substrate
n/a
Meas. Tech.
ChEMBL_85812 (CHEMBL878439)
IC50
1.58±n/a nM
Citation
 ter Laak, AM; Venhorst, J; Donné-Op den Kelder, GM; Timmerman, H The histamine H1-receptor antagonist binding site. A stereoselective pharmacophoric model based upon (semi-)rigid H1-antagonists and including a known interaction site on the receptor. J Med Chem 38:3351-60 (1995) [PubMed]  Article 
Target
Name:
Histamine H1 receptor
Synonyms:
HISTAMINE H1 | HRH1 | HRH1_CAVPO
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
55641.53
Organism:
Cavia porcellus (domestic guinea pig)
Description:
Guinea pig cerebellum was used in binding assay.
Residue:
488
Sequence:
MSFLPGMTPVTLSNFSWALEDRMLEGNSTTTPTRQLMPLVVVLSSVSLVTVALNLLVLYAVRSERKLHTVGNLYIVSLSVADLIVGAVVMPMSILYLHRSAWILGRPLCLFWLSMDYVASTASIFSVFILCIDRYRSVQQPLRYLRYRTKTRASATILGAWLLSFLWVIPILGWHHFMAPTSEPREKKCETDFYDVTWFKVMTAIINFYLPTLLMLWFYIRIYKAVRRHCQHRQLINSSLPSFSEMKLKLENAKVDTRRMGKESPWEDPKRCSKDASGVHTPMPSSQHLVDMPCAAVLSEDEGGEVGTRQMPMLAVGDGRCCEALNHMHSQLELSGQSRATHSISARPEEWTVVDGQSFPITDSDTSTEAAPMGGQPRSGSNSGLDYIKFTWRRLRSHSRQYTSGLHLNRERKAAKQLGCIMAAFILCWIPYFVFFMVIAFCKSCSNEPVHMFTIWLGYLNSTLNPLIYPLCNENFRKTFKRILRIPP
  
Inhibitor
Name:
BDBM50131441
Synonyms:
9,13b-dihydro-1H-dibenzo[c,f]imidazo[1,5-a]azepin-3-amine | CHEMBL1106 | EPINASTINE | Elestat | Flurinol | WAL 80 | WAL 801 | epinastine hydrochloride
Type:
Small organic molecule
Emp. Form.:
C16H15N3
Mol. Mass.:
249.3104
SMILES:
NC1=NCC2N1c1ccccc1Cc1ccccc21 |t:1|
Structure:
Search PDB for entries with ligand similarity: